【摘要】 目的 了解我国健康青年人一过性下食管括约肌松弛(TLESR)与酸反流的关系及脂肪含量不同的饮食对健康人TLESR和酸反流的影响。方法 采用下食管括约肌(LES)袖套式测压管、单晶锑pH测定管，同步记录10名志愿者空腹1小时及餐后4小时内的LES压力和食管pH值。结果 酸反流均发生在LES压力低于2mmHg时，其中90.4%发生在TLESR时。餐后酸反流显著增加(P<0.01)，TLESR及TLESR伴酸反流率也显著增加(P均<0.01)。低脂餐与高脂餐对酸反流、TLESR及TLESR伴酸反流率的影响差异无显著性意义(P均>0.05)。结论 TLESR是健康人酸反流发生的主要机制，健康人餐后酸反流增加主要是因为TLESR及TLESR伴酸反流增加。高脂餐并不增加健康人的TLESR及酸反流。

    

Transient lower esophagealsphincter relaxation in young adults

SHU Jing,ZHANG Qiyu.

    Zhejiang University Medical School Affiliated Sir Run Run Shaw Hospital,Hangzhou,310016

【Abstract】 Objectives (1)The relationship between acid reflux and transient lower esophageal sphincter relaxation (TLESR ) was investigated.(2) The effects of high and low fat meal on TLESR and acid refluxobserved .Methods Lower esophageal sphincter ( LES ) pressure andintraluminal acidity were silmultaneously recorded 1 hour before and 4 hours after themeal using esophageal manometry and pH monitoring devices in 10 young volunteers.Results Acidreflux occurred definitely at LES pressure below 2 mmHg ; 90.4% of which being concomitantwith TLESR . After the meal the rates of acid reflux, TLESR and that of TLESR+acid refluxaugmented apparently ( P<0.01,P<0.01,P<0.01 respectively ) . No significantdifference was noted between the effects of high and low fat meals on above rates(P>0.05,P>0.05,P>0.05 accordingly ) .Conclusions (1)TLESRseemed to be the main factor influencing acid reflux in normal subject.(2)The increase inpostprandial acid reflux was likely due to rise in rates of TLESR and TLESR+acidreflux.(3)High fat meal did not exert effect on TLESR and acid reflux in healthyindividual.

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