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经DNA测序证实的肝豆状核变性基因突变热区的研究
http://www.100md.com 《中华神经科杂志》 1998年第1期
肝豆状核变性||基因突变|||DNA测序,关键词:
     王柠 吴志英 慕容慎行 林珉婷 方玲 350005 福州,福建医科大学附属第一医院神经内科 中华神经科杂志 1998 0 31 1


    关键词:肝豆状核变性;;基因突变;;;DNA测序 期刊 zhsjkzz 0 论著 fur -->


    

【摘要】 目的 探讨系统性红斑狼疮患者肾功能损害的敏感指标。方法 用99m Tc-DTPA作示踪剂,对58例患者进行常规肾显像,测定肾小球滤过率,并对肾图进行定量分析。结果 用Gates法计算的肾小球滤过率与肌酐清除率有高度相关性。肾小球滤过率的改变与患病时间长短无关。本组中肾图异常者为50%,

    但肾图经定量分析后,半排时间、15分钟残余率的异常率分别为93.1%和85.3%,远较临床综合判断有67.3%的患者肾功能受损为高。即使是肾小球滤过率在正常范围时,亦有88.5%的患者显示半排时间延长。此外,半排时间与15分钟残余率对肾异常的检出率比尿素氮和(或)肌酐明显为高。结论 对肾图进行定量分析可提高其对肾脏功能损害判断的敏感性。

    
Clinical Significance of Renal Imaging in Pateints with SLE by Quantitative Renogram Luo Diqing,Zhong Xingfu,Xu Deqing,et al.Department of Dermatology,Sun Yat-senUniversity of Medical Sciences,Guangzhou 510120

    
Abstract Objective To investigate the sensitive indexes which can diagnoseearly renal damage in SLE. Methods We used radioisotope renogram with 99m Tc-DTPA as a tracer, to examine the glomerular filtration rate (GFR) and assessedrenogram quantitatively in 58 patients. Results The results showed that the GFR calculated by the Gates method correlated well with creatinine clearance rate, but had no correlation with the duration of the disease. Only 50% of the patients showed abnormal renogram. There were abnormal half clearance time and 15-minute residual ratio in 93.1% and 85.3% of the patients respectively after quantitative renogram analysis. However, there were only 67.3% of patients had renal damage clinically, the positive rates of half clearance time and 15-minute residual ratio were much higher than those found by clinical examination. Even when GFR was normal, there were 88.5% of the patients showed prolonged half clearance time. We also found that half clearance time and 15-minute residual ratio were much more sensitive than blood urea nitrogen or/and creatinine clearance rate determination. Conclusion The results suggest that quantitative renogram analysis may increase the sensitivity in assessing the renal damage.

    
Key words Lupus erythematosus,systemic Renogram

    


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