【摘要 】 目的 探讨肺癌脑转移综合治疗的疗效及预后影响因素。方法 回顾性分析了1990年1月～1996年12月采用不同方法治疗的252例肺癌脑转移患者生存期与生存率。结果 转移灶手术切除及γ-或X-刀治疗辅以放疗、化疗以及放疗与化疗联合组的中位生存期及1、2年生存率明显高于单纯放疗与化疗组(P<0.01及P<0.05)，肺癌的病理类型对生存期与生存率无明显影响(P>0.05)；单发转移及无颅外转移者生存期(中位生存期分别为8.5和8.5个月)与生存率(1年生存率分别为35%和29%，2年生存率分别为11%和8%)明显高于多发转移及伴颅外血行转移者(P<0.01);高年龄者(≥50岁)1年生存率(29%)明显高于低年龄组(15%，P<0.05)。结论 转移灶的手术切除及γ-或X-刀治疗加放疗和化疗是治疗肺癌脑转移患者的首选方法，转移的数量与部位多少及年龄是影响预后的因素。

    

ZHANG Shucai, YANG Xinjie, ZHAO Aiguo

Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149

【Abstract 】 Objective Toevaluate the efficacy of combination therapy and prognostic factors for lung cancerpatients with brain metastasis. Methods The survival time and survival rates withvarious therapeutic methods were analyzed retrospectively in 252 patients with brainmetastasis . Results The median survival time and 1,2 year survival rates in surgery andX-knife plus radio-chemotherapy group and combination therapy of radiotherapy withchemotherapy were significantly longer than radio-chemotherapy alone group (P<0.01 andP<0.05); the pathological type of lung cancer did not affect the survival time andsurvival rate (P>0.05); the survival time and survival rate of single brain metastasis(median survival time was 8.5 months 1,2 year survival rates were 35% and 11%respectively) and non-extrabrain metastasis (8.5 months, 29%, 8%) were much longer thanmultiple brain metastasis and extrabrain metastasis (P<0.01); the 1 year survival rateof older patients(≥50 years ......