关键词:肺疾病,阻塞性;肺心病;血管内皮;血液动力学
【摘要 】 目的 探讨慢性阻塞性肺疾病(COPD)和肺心病时血循环内皮细胞、血液动力学的变化及意义。方法 运用右心导管检查技术和血循环内皮细胞(CEC)分离技术,用硫巴比妥法及羟胺法测定血丙二醛(MDA)及超氧化物岐化酶(SOD)。结果 肺心病组肺动脉平均压[(mPAP)3.76±0.75 kPa、血CEC数量每0.9微升为16.70±2.65与COPD组(8.48±2.23)比较,差异有显著性(P<0.01),血CEC数量与动脉血氧分压(PaO2 )比较呈显著负相关(r=0.9423,P<0.001),血CEC数量与肺动脉压比较呈显著正相关(r=0.8270,P<0.001),肺心病组丙二醛(MDA)、超氧化物歧化酶(SOD)与COPD组比较,差异有显著性(P<0.01)。结论 缺氧可加重血管内皮细胞损伤。
Change of hymodynamics andcirculating endothelial cells in chronic obstructive pulmonary diseases (COPD) and corpulmonale patients Peng Wenhong, Zou Xiaying, Mao Baoling, et al. General Hospital Commission of Science Technology andIndustry of National Defence Beijing 100101
【Abstract 】 Objective Toinvestigate the vascular endothelial injuries by observing the changes of circulatingendothelial cells (CEC) numbers in blood and hemodynamics in COPD and cor pulmonalepatients. Method The arterialcatheterion technique and CEC collection technique were used, superoxide dismutase (SOD)and malondialdyhyde(MDA) levels were determined respectively. Result mPAP (3.76±0.75 kPa) and CEC (16.70±2.65/0.9 μl), MDA (6.98±1.47 μmol/L) inthe chronic cor pulmonale are higher than that of mPAP (2.09±0.41 kPa) and CEC (8.48±2.23 μl) in COPD ,the numbers of CEC are adverselycorrelated to PaO2 ( γ=0.9423,P<0.001)and positively correlated with mPAP ( γ=0.8270,P<0.001).superoxide dismutase(SOD) was decreased. Conclusion mPAP 、CEC are higher in corpulmonale than that in COPD ,CEC numbers rise when the PaO2 was lowered,hypoxia may worsen the vascular endothelial injuries.
【Key words 】 Lung disease,obstructive Pulmonaryheart disease Endothelium,vascular
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