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编号:10924513
肝细胞肝癌患者肿瘤/睾丸抗原SSX-1及NY-ESO-1mRNA的表达意义
http://www.100md.com 吴力群, 王新建, 卢 云, 张 斌, 杨金镛
肝细胞癌;SSX-1;NY-ESO-1;逆转录聚合酶链反应,吴力群,王新建,卢云,张斌,杨金镛,通讯作者,:,Expre
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     吴力群, 王新建, 卢云, 张斌, 杨金镛, 青岛大学医学院附属医院肝胆外科 山东省青岛市 266003

    吴力群, 男, 1958-10-31生, 江苏省丹阳市人, 汉族, 1982年青岛医学院本科毕业, 主任医师, 主要从事肝胆外科专业.

    通讯作者: 吴力群, 266003, 山东省青岛市, 青岛大学医学院附属医院肝胆外科. jiaoqin@mail.qdcatv.com.cn

    电话: 0532-82911999 传真: 0532-82911999

    收稿日期: 2005-03-31 接受日期: 2005-04-09

    Expression of cancer-testis antigens SSX-1 and NY-ESO-1 mRNA in hepatocellular carcinoma and its clinical significance

    Li-Qun Wu, Xin-Jian Wang, Yun Lu, Bin Zhang, Jin-Yong Yang

    Li-Qun Wu, Xin-Jian Wang, Yun Lu, Bin Zhang, Jin-Yong Yang, Department of Hepatobiliary Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China

    Correspondence to: Li-Qun Wu, Department of Hepatobiliary Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China. jiaoqin@mail.qdcatv.com.cn

    Received: 2005-03-31 Accepted: 2005-04-09

    Abstract

    AIM: To investigate the expression of SSX-1 and NY-ESO-1 mRNA in hepatocellular carcinoma (HCC) and their clinical significances.

    METHODS: The expression of SSX-1 and NY-ESO-1 mRNA were detected in the cancer tissues, the corresponding cancer-adjacent tissues and the peripheral blood of 26 patients with HCC as well as of 20 controls by reverse transcription polymerase chain reaction (RT-PCR). A randomized sample of the RT-PCR products was selected for DNA sequencingto examine the reliability of results.

    RESULTS: The positive rates of SSX-1 and NY-ESO-1 mRNA expression were 61.5%(16/26) and 11.5% (3/26), respectively, in cancer tissues, and they were 46.2%(12/26) and 3.8%(1/26) in the peripheral blood. HCC patients, whose peripheral blood expressed SSX-1 or NY-ESO-1 mRNA, also expressed the same gene in their cancer tissues. SSX-1 and NY-ESO-1 mRNA were not expressed in cancer-adjacent tussues, and tissues and peripheral blood of the controls ......

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