黑龙江地区乙型肝炎病毒耐药变异与基因型
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李 迪, 张淑云, 谷鸿喜, 程险峰, 王晓燕
乙型肝炎;基因型;拉米夫定;YMDD基因变异;耐药,李迪,谷鸿喜,张淑云,程险峰,王晓燕,通讯作者,:,Drug-resistantmutationandg
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李迪, 谷鸿喜 , 哈尔滨医科大学微生物学教研室 黑龙江省哈尔滨市 150086
张淑云 , 哈尔滨医科大学附属第二医学院科研实验中心
黑龙江省哈尔滨市 150086
程险峰 , 黑龙江省医院南岗分院泌尿外科 黑龙江省哈尔滨市 150001
王晓燕 , 哈尔滨医科大学附属第二医学院传染科 黑龙江省哈尔滨市 150086
李迪, 女, 1971-01-19生, 黑龙江省哈尔滨人, 汉族, 2002年哈尔滨医科大学病原学硕士, 现为哈尔滨医科大学病原学博士生, 主要从事肿瘤相关病毒的研究.
日本健康科学基金资助项目, No. 0109
哈尔滨医科大学博士创新基金项目
通讯作者 : 谷鸿喜, 150086, 黑龙江省哈尔滨市南岗区学府路194号, 哈尔滨医科大学微生物学教研室. hxgu2432@163.com
电话: 0451-86685122 传真: 0451-86685122
收稿日期: 2005-04-15 接受日期: 2005-05-06
Drug-resistant mutation andgenotype of hepatitis B virus Heilongjiang Province
Di Li, Shu-Yun Zhang, Hong-Xi Gu, Xian-Feng Cheng, Xiao-Yan Wang
Di Li, Hong-Xi Gu, Department of Microbiology, Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Shu-Yun Zhang, Experimental Center, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Xian-Feng Cheng, Urinary Surgery, the Provincial Hospital of Heilongjiang, Harbin 150001, Heilongjiang Province, China
Xiao-Yan Wang, Department of Infectious Diseases, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Supported by Japan Health Science Foundation, No.0109 and Doctor Foundation of Harbin Medical University
Correspondence to: Hong-Xi Gu, Department of Microbiology, Harbin Medical University, 194 Xuefu Road, Nangang District, Harbin 150086, Heilongjiang Province, China. hxgu2432@163.com
Received: 2005-04-15 Accepted: 2005-05-06
Abstract
AIM: To determine the relationship between YMDD mutation of hepatitis B virus (HBV) and HBV genotypes during lamivudine treatment.
METHODS: HBV genotypes were determined by nested polymerase chain reaction (PCR) with six pairs of HBV genotype-specific primers (A to F). Then YMDD mutations were detected by real-time fluorescent PCR in serum specimens from 106 hepatitis B patients receiving lamivudine therapy ......
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