裸鼠人涎腺黏液表皮样癌多药耐药模型逆转耐药的体内研究
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李 焰, 吴军正, 刘 斌, 李 峰, 惠延
黏液表皮样癌;逆转模型;裸鼠;多药耐药性,李焰,吴军正,刘斌,李峰,惠延平,黄晓峰,通讯作者,:,Reversalofmultidrugre
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李焰, 吴军正,刘斌, 李峰,中国人民解放军第四军医大学口腔医院口腔生物学教研室 陕西省西安市 710032
惠延平,中国人民解放军第四军医大学病理教研室 陕西省西安市 710032
黄晓峰,于华,中国人民解放军第四军医大学电镜中心 陕西省西安市 710032
李焰, 女,1952-12-22生,湖北省孝感市人,汉族,中国人民解放军第四军医大学口腔医院口腔生物学教研室, 副主任技师,主要从事口腔生物学研究.
国家自然科学基金资助课题,No.30371551
通讯作者:吴军正,710032, 陕西省西安市,中国人民解放军第四军医大学口腔医院口腔生物学教研室. liyanly@fmmu.edu.cn
电话: 029-83376173 传真:029-83376232
收稿日期:2005-06-06 接受日期:2005-06-13
Reversal of multidrug resistance in a nude mice model induced by humansalivary gland mucoepidermoid carcinoma cell line MEC-1/5-FU in vivo
Yan Li, Jun-Zheng Wu, Bin Liu, Feng Li, Yan-Ping Hui, Xiao-Feng Huang, HuaYu
Yan Li, Jun-Zheng Wu, Bin Liu, Feng Li, Department of Oral Biology,College of Stomatology, the Fourth Military Medical University, Xi'an710032, Shaanxi Province, China
Yan-Ping Hui, Department of Pathology, the Fourth Military MedicalUniversity, Xi'an 710032, China
Xiao-Feng Huang, Hua Yu, Center of Electron Microscopy, the FourthMilitary Medical University, Xi'an710032, China
Supported by National Science Foundation of China, No. 30371551
Correspondence to: Jun-Zheng Wu, Department of Oral Biology,College of Stomatology, the Fourth Military Medical University, Xi'an710032, Shaanxi Province, China. liyanly@fmmu.edu.cn
Received: 2005-06-06 Accepted:2005-06-13
Abstract
AIM: To establish the multidrug resistance (MDR) model in nude miceusing human salivary gland mucoepidermoid carcinoma cell line MEC-1/5-FUand to observe the reversal of multidrug resistance.
METHODS: MEC-1/5-FU cells (0.2 mL, 1×1010/L)were injected into the backs of 20 six-week-old nude mice subcutaneously.After the tumor was developed, the mice were randomly divided into 4groups, each containing 5 mice. The mice in the four groups wererespectively injected with 5-FU (20 mg/kg), HMBA (800 mg/kg), 5-FU (10mg/kg) plus HMBA (400 mg/kg) and normal saline (control) peritoneally ......
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