三氧化二砷抑制小鼠体内肝癌细胞增殖的实验研究
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唐印华, 田永刚, 刘铁夫, 徐洪雨, 庄丽维,
三氧化二砷;肝癌;小鼠,唐印华，刘铁夫，徐洪雨，庄丽维，梁桃，姜爱民，,田永刚，,唐印华，,通讯作者：,Inhibitoryeffectofarsenic
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唐印华，刘铁夫，徐洪雨，庄丽维，梁桃，姜爱民，哈尔滨医科大学第一临床医学院消化内科 黑龙江省哈尔滨市 150001
田永刚，哈尔滨医科大学第四临床医学院普通外科 黑龙江省哈尔滨市 150001
唐印华，女，1974-06-13生，黑龙江省大庆市人，汉族，1997年哈尔滨医科大学本科毕业，2002年哈尔滨医科大学消化内科硕士研究生，讲师，主要从事消化系统肿瘤的基础与临床研究.
卫生部指导性课题，No. 98-2-269
黑龙江省九五攻关重大课题资助项目，No. G98L19-1
通讯作者：唐印华，150001，黑龙江省哈尔滨市南岗区邮政街23号，哈尔滨医科大学第一临床医学院消化内科.
tangyinhua-302@163.com
电话：0451-53643849-5263
收稿日期：2005-06-30 接受日期：2005-07-15
Inhibitory effect of arsenic trioxide on proliferation of hepatoma cells in mice
Yin-Hua Tang, Yong-Gang Tian, Tie-Fu Liu, Hong-Yu Xu, Li-Wei Zhuang, Tao Liang, Ai-Min Jiang
Yin-Hua Tang, Tie-Fu Liu, Hong-Yu Xu, Li-Wei Zhuang, Tao Liang, Ai-Min Jiang, Department of Gastroenterology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Yong-Gang Tian, Department of General Surgery, the Forth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Supported by the 9th Five-Year Plan of Science and Technology of Heilongjiang Province, No. G98L19-1, and the Directive Project of Ministry of Health, No. 98-2-269
Correspondence to: Dr. Yin-Hua Tang, Department of Gastroenterology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China. tangyinhua-302@163.com
Received: 2005-06-30 Accepted: 2005-07-15
Abstract
AIM: To explore the arsenic trioxide(As2O3)-induced inhibition of the proliferation of mouse hepatoma cells in vivo.
METHODS: The mice bearing H22 solid and ascetic hepatoma cells were treated with different concentrations of arsenic trioxide. The growth of the solid tumor and the survival of the ascetic tumor-bearing mice were observed. The expression of proliferating cell nuclear antigen (PCNA) and cyclinD1 of the tumor cells were examined by immunohistochemical methods ......
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