二甲基亚硝胺诱发大鼠肝纤维化模型中库普弗细胞与星状细胞的分布
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朴金花, 金京顺, 崔京淑, 朴东明
朴金花，金京顺，崔京淑，朴东明，,通讯作者：,DistributionofKupffercellsandhepaticstellatece
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朴金花，金京顺，崔京淑，朴东明，延边大学医院病理科 吉林省延吉市 133000
通讯作者：朴东明,133000, 吉林省延吉市局子街119号，延边大学医院病理科. pdm11172000@yahoo.com.cn
电话：0433-2660121 传真：0433-2513610
收稿日期: 2005-08-03 接受日期: 2005-08-10
Distribution of Kupffer cells and hepatic stellate cells in dimethylnitrosamine-induced liver fibrosis in rats
Jin-Hua Piao, Jing-Shun Jin, Jing-Shu Cui, Dong-Ming Piao
Jin-Hua Piao, Jing-Shun Jin, Jing-Shu Cui, Dong-Ming Piao, Department of pathology, Hospital of Yanbian University, Yanji 133000, Jilin Province, China
Correspondence to: Dong-Ming Piao, Department of pathology, Hospital of Yanbian University, 119 Juzi Street, Yanji 133000, Jilin Province, China. pdm11172000@yahoo.com.cn
Received: 2005-08-03 Accepted: 2005-08-10
Abstract
AIM: To investigate the distribution and significance of Kupffer cells (KCs) and hepatic stellate cells (HSCs) in dimethylnitrosamine(DMN)-induced liver fibrosis in rats.
METHODS: Rat liver fibrosis was induced by peritoneal injection of DMN (10 g/L) for 4 wk. The activities of serum alanine transaminase (ALT), aspartate transaminase (AST), the contents of total proteins (TP), the ratio of liver/body weight and the area density of collagenous fiber were examined 4 and 7 wk after injection. Meanwhile, the pathological changes of the liver tissues were observed under light microscope. The expression of ED1 and α-smooth muscle actin (α-SMA) were detected by immunohistochemical SP method.
RESULTS: Compared with those in the control group, the levels of ALT and AST were significantly elevated 4 and 7 wk after injection (4 wk:1201.91±215.04, 5741.15±1000.20 nkat/L vs 398.91±106.35, 1365.27±435.09 nkat/L, P <0.01; 7 wk: 745.15±413.42, 2355.47±1418.62 nkat/L vs 289.72±43.01, 1018.54±215.04 nkat/L, P <0.05). TP content was significantly decreased 4 wk after injection (50.32±9.81 g/L vs 69.67±6.09 g/L, P <0.01), but returned to normal after 7 wk ......
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