【摘要】 目的 研究肝细胞生长因子(HGF)受体即c-met蛋白在胃癌组织标本中的表达及临床意义。 方法 应用免疫组织化学的方法检测53例临床手术切除的胃癌标本及相应的胃黏膜标本c-met的表达。 结果 c-met蛋白不同程度的表达于正常胃黏膜、胃癌组织中，正常胃黏膜阳性表达率为22.64%(12/53)，胃癌组织阳性表达率为75.47%(40/53)。胃癌组织中c-met蛋白的表达水平与形态学分类、临床分期、肝转移无关、与组织学分类、淋巴转移、浸润深度有关。 结论 c-met蛋白在胃癌组织中及其配对的正常胃黏膜中存在不同程度的表达，在肿瘤中的表达水平明显高于正常黏膜。过度表达c-met是胃癌的一种特有的现象，证实c-met是一种高表达的原癌基因。

    【关键词】 c-met;肝细胞生长因子;胃癌;免疫组织化学

    The clinical significance of the expression of c-met in gastric cancer

    ZHU Chang-hong，ZHANG Rui-kui，WEI Ya，et al.

    Medical College of Chinese People's Armed Police Forces，Tianjin300162，China

    【Abstract】 Objective To investigate the expression of c-met protein levels in specimen of gastric cancer and its roles in the pathogenesis of gastric cancer.Methods The immunohistochemistry technique was applied to examine the expression of c-met protein in53specimen of gastric cancer.Results C-met protein expression of variable intensi-ty and extend was detected in the normal gastric mucosa and adenocarcinomas in gastric cancer.The positive expres-sion scores in normal mucosa was22.64%(12/53).75.47%(40/53)of gastric cancer expressed c-met more in-tensely and extensively than matched normal gastric mucosa ......