从肠肌间神经丛抑制性神经递质的改变探讨IBS不同亚型的发病机制
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徐俊荣, 罗金燕, 尚 磊,孔武明
便秘型;腹泻型I;肠易激综合征;一氧化氮,徐俊荣,罗金燕,孔武明，,尚磊，,徐俊荣，,通讯作者：,Roleofinhibito
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徐俊荣, 罗金燕,孔武明，西安交通大学第二医院消化科 陕西省西安市 710004
尚磊，中国人民解放军第四军医大学卫生统计学教研室 陕西省西安市 710033
徐俊荣，女, 1970-2-15生, 陕西省西安市人, 汉族, 2001年第四军医大学硕士, 主要从事消化系统基础与临床研究.
通讯作者：罗金燕, 710004, 陕西省西安市西五路157号，西安交通大学第二医院消化科. ljy18272@163.com
电话：029-87678758 传真: 029-87678758
收稿日期：2005-09-21 接收日期: 2005-09-30
Role of inhibitory neurotransmitter of myoentericplexus in carcinogenesis of irritable bowel syndrome with differentsubtypes
Jun-Rong Xu, Jin-Yan Luo, LeiShang, Wu-Ming Kong
Jun-Rong Xu, Jin-Yan Luo, Wu-Ming Kong, Department of Gastroenterology, the Second Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Lei Shang, Department of Health Statistics, the Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Correspondence to: Professor Jin-Yan Luo, Department of Gastro-enterology, the SecondHospital of Xi’an Jiaotong University, Xi’an 710004, 157 Xiwu Road,Shanxi Province, China. ljy18272@163.com
Received: 2005-09-21 Accepted:2005-09-30
Abstract
AIM: To investigate the role of inhibitory neurotransmitter of myoenteric plexus in the carcinogenesis of constipation and diarrhea-predominant irritable bowel syndrome (C-IBS and D-IBS) in rats.
METHODS: Rat model of D-IBS was established by intracolonic instillation of acetic acid and restraint stress, while the positive and blank control were designed; Rat model of C-IBS was established by stomach irrigation with 0-4°C cool water daily for 14 d, while the positive and blank control were also designed. The bowel movement, the properties of fecal pellets, visceral sensitivity, and the content of nitric oxide (NO) in the myoenteric plexus were detected in the rats of each group.
RESULTS: The contraction frequency of the abdominal muscle in D-IBS group was significantly enhanced as compared with that in C-IBS, positive and blank control group (1 ......
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