当前位置: 首页 > 期刊 > 《中华现代临床医学杂志》 > 2005年第19期
编号:10780503
原发性高血压患者C-反应蛋白与动脉粥样硬化的关系
http://www.100md.com 《中华现代临床医学杂志》 2005年第19期
C-反应蛋白,,原发性高血压;C-反应蛋白;动脉粥样硬化,1对象与方法,2结果,3讨论,【参考文献】
     【摘要】 目的 对不同程度的原发性高血压患者进行血浆高敏C-反应蛋白(C-reactive protein,CRP)检测,探讨超敏C-反应蛋白(hs-CRP)在动脉粥样硬化疾病中的临床意义。方法 对30例1~2级原发性高血压患者(第1组)和30例3级原发性高血压患者(第2组)进行hs-CRP、内皮素、同型半胱氨酸(HCY)和血脂检测、颈动脉超声检查,与除外原发性高血压、冠心病、糖尿病以及各种感染、肿瘤患者进行比较分析。结果 第2组hs-CRP、内皮素、HCY浓度明显高于第1组,差异有显著性(P<0.05)。两组分别与对照组比较差异有非常显著性(P<0.01)。第2组颈动脉硬化最严重。血脂除低密度脂蛋白胆固醇(LDL-C)两组间比较差异有显著性外(P<0.05),均无明显差异。结论 原发性高血压患者血液中hs-CRP、内皮素、HCY浓度与原发性高血压和颈动脉粥样硬化程度呈正相关。对血脂正常的患者测定hs-CRP尤其重要,对血脂和hs-CRP两个危险因子联合测定,对心血管事件的发生会有更高的预报作用。

    【关键词】 原发性高血压;C-反应蛋白;动脉粥样硬化

    Relationship between Hs-CRP and atherosclerosis in patients with essential hypertension

    LU Hui-hua,REN Jian-ying.Department of Geriatrics,Xuhui District Central Hospital,Shanghai 200031,China

    【Abstract】 Objective To explore the clinical significance between plasma levels of high-sensitive C reactive protein (hs-CRP) and atherosclerosis in patients with essential hypertension.Methods By measuring hs-CRP,endothelin,homocysteine(HCY),lipid and caroid artery echocardiography,ninety patients were divided into three groups equally,among them,the first group suffered 1-2 degree essential hypertension;the second group suffered 3 degree essential hypertension;excluding hypertension,coronary heart disease,diabetes,infections disease and tumour,control group as a third group was analyzed.Results The levels of hs-CRP,endothelin and HCY in the second group were markedly elevated than in those of the first group(P<0.05).The two groups of essential hypertension were compared respectively with the control group,there was significant statistic differences(P<0.01).The lesions of caroid artery atherosclerosis were serious in the second group.The analysis of hyperlipidemia in two groups,except LDL-C(P<0.05),there was no statistic differences.Conclusion The levels of hs-CRP,endothelin,HCY were positively related to the degree of hypertension and athersclerosis in hypertensive patients.Hs-CRP is a very important factor,especially the patients have a normal lipid.The risk factors of hs-CRP and lipid are the prognostic factors for assessment of cardiovascular events. ......

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