摘要：目的：研究急性冠脉综合征(ACS)早期应用辛伐他汀对血脂、缺血事件发生的影响。方法：60例ACS患者被随机分为对照组(n=30)和治疗组(n=30，用辛伐他汀治疗)观察用药前后血脂、缺血事件发生情况。结果：对照组治疗前后血脂无显著变化(P>0.05)。与对照组相比，治疗组用药后血脂明显下降(P<0.05)，缺血事件发生率明显下降(X2=4.72，P<0.05)。两组治疗前、后肝、肾功能，肌酸磷酸激酶水平均无明显变化。结论：ACS早期应用辛伐他汀可明显降低缺血事件发生率。

    关键词：急性冠脉综合征；辛伐他汀；缺血事件

    Evaluation of Simvastatin in the Treatment of Acute Coronary Syndrome

    XIE Xiao-ming, et al

    (Affiliated Hospital of Guangdong Medical College, Guangdong Zhanjiang 524001,China)

    Abstract：Objective： To observe the influence of early simvastatin treatment on serum lipids and ischemic events in patients with acute coronary syndrome(ACS).Method： Sixty patients with ACS were divided into control group(n=30) and therapy group(n=30) randomizely, and the changes of serum lipeid and the incidence of ischemic events were observed.Result： After treatment of simvastatin, the levels of serum lipids and incidence of ischemic events significantly decreased compared with those of control groups (all p<0.05). Before and after treatment, the levels of serum lipids in control group, renal function, Liver function and creatine phosphokinase in both two groups had no change. Conclusion： Early simvastatin treatment could significantly reduce incidence of ischemic events in patients of ACS. ......