摘要：目的:为观察高血压病患者代文(缬沙坦胶囊)治疗前后血浆纤维蛋白原[Fbg]和血清钾浓度的变化。方法:采用热浸淀比浊法和全自动生化分析仪分别测定23例正常人和53例高血压病患者代文治疗前和治疗12周后的血浆Fbg和血清钾浓度。结果:治疗前高血压病患者的血浆Fbg浓度明显高于正常人(4.32±0.46 g/L比3.5±0.34mmol/L，P<0.01)，而血清钾浓度明显低于正常人(3.5±0.34g/L比3.7±0.28 4mmol/L,P<0.01)；代文治疗后血浆Fbg浓度降到3.24±0.35 g/L,P<0.01),而血清钾浓度无明显变化(P>0.05)。结论:提示高血压病患者的血浆Fbg水平升高而血清钾浓度偏低，代文在降低血压的同时降低血浆Fbg水平，但对血清钾浓度影响不大。

    关键词：高血压病；纤维蛋白原；血清钾；代文

    Changes of Plasma Fibrinogen and Serum K+ Concentration in Patients with Essential Hypertension Before and After Diovan Treatment

    ZHU Xiu-long, WEI Zhi-bao

    (Gaozhou People’s Hospital,Guangdong Gaozhou 525200,China)

    Abstract： Objective:To investigate the changes of plasma fibrinogen and serum K+ and concentration in patients with essential hypertension before and after diovan (Caps Valsartan)treatment.Method:Plasma fibrinogen and serum K+ and concentration were measured with therncoprepilatic turbidimetry automtic biochemical analysis apparatus in 23 norotensive controls and 53 patients with essential hypertension before and after ks of treatment with Diovan. Result: The baseline concentrations of plasma fibrinogen were significantly higher in hypertensive patients than in nomotonsive controls (4.32±0.46g/L vs3.5±0.34g/L,P<0.01).while the levels of serum K+ were lower in hypertensive patiens than in normotensivecontrols (3.50±0.34mmol/Lvs.3.7±0.28mmol/L,P<0.01).After 12 weeks treatment of Diovan ,plasma fibrinogen concentrations had fallen to 3.24±0.35g/L(P<0.01).while serum K+ concentrations didn’t change.Conclusion: Plasma fibrinogen levels are higher while serum K+ concentrations are lower in patients with hypertension. Diovan can decrease blood pressure as well as plasma fibrinogen concentrations ,but doesn’t change the levels of serum K+. ......