摘要：目的:探讨多囊卵巢综合征(Polycystic ovary syndrome ,PCOS)血清肿瘤坏死因子(Tumor necrosis factor, TNF)-α与胰岛素抵抗的关系。方法:采用放射免疫法检测30例PCOS患者及35例正常对照组血清TNF-α、促黄体生成素(LH)/促卵泡素(FSH)、睾酮(T)及空腹胰岛素，用氧化酶法检测血浆葡萄糖浓度。结果: PCOS组血清TNF-α水平、LH/ FSH、T、胰岛素抵抗指数(IRI (ln))均显著高于对照组(P<0.05)；血清TNF-α水平与IRI (ln)、LH/FSH、T呈显著正相关(r分别为0.57、0.47、0.65)。结论: TNF-α可能促进PCOS胰岛素抵抗的发生,两方面因素相互作用加重了PCOS的病理生理改变。

    关键词：多囊卵巢综合征；TNF-α；胰岛素抵抗

    Detection of TNF-α in Serum from Patients with Polycystic Ovary Syndrome

    ZOU Qian，SUN Ming-qin

    (Family Planning Service Station,Shandong Haiyang 265100,China)

    Abstract: Objective: In order to investigate the relationship between leptin and TNF-α and insulin resistance in polycystic ovary syndrome. Method: Blood samples for TNF-α、LH/FSH、testone、fasting insulin and glucose detection from 30 patients with PCOS and 35 cases as control group were analyzed by radioimmunoassay or oxidase test. It showed that serum TNF-α、LH/FSH ratio and IRI(ln) in patients with PCOS were significantly higher than that in control group(P<0.05), TNF-α level was positively related with IRI(ln) and LH/FSH(r =0.57、0.47、0.65). It was suggested that TNF-α accelerate insulin resistance , the interaction of two factors aggravate the change of pathophysiology in PCOS. ......