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编号:10781698
尼莫地平、脑活素对缺氧缺血性脑病新生儿预后的影响
http://www.100md.com 《河北医学杂志》 2005年第10期
尼莫地平,,婴儿;新生;脑缺氧;脑缺血,1资料与方法,2结果,3讨论,参考文献:
     摘要:目的:探讨尼莫地平、脑活素对缺氧缺血性脑病(Hypoxic-Ischemic Encephalopathy ,HIE)新生儿预后的改善及保护作用。方法:将146例HIE患儿随机分为观察组(76例)和对照组(70例)。对照组行常规治疗,观察组在常规治疗的基础上于生后48h内加用尼莫地平、脑活素治疗。所有患儿日龄12~14d和26~28d行新生儿行为神经评分(NBNA);3、6个月龄时行智测检查。结果:中、重度HIE,观察组两次NBNA评分和智能发育评估均优于对照组(P<0.05,P<0.01)。结论:早期应用尼莫地平、脑活素能明显改善中、重度HIE患儿预后。

    关键词:婴儿;新生;脑缺氧;脑缺血

    Effects of Nimodipine and Cerebrolysin on Prognosis of Newborn with Hypoxic-Ischemic Encephalopathy

    ZHANG Mei-ying, ZHANG Li-hui, WU Hong-xuan

    (Anyang Iron & Steel Company General Staff Hospital, Henan Anyang 455004, China)

    Abstract: Objective:To study the effects of nimodipine and cerebrolysin on prognosis of Newborn with Hypoxic-Ischemic Encephalopathy. Method:One hundren and forty-six newborns with HIE were randomly divided into 2 groups.In control group(n=70),the treatment was common.In experimental group(n=76), Nimodipine and cerebrolysin were used within 48 hours after birth except for routine therapy. NBNA was performed at 12~14 days and 26~28 days old in all patients;Intelligence test was also performed at 3rd and 6th month after birth. Result:The moderate and severe HIE,NBNA score and mental development were better in experimental group than those in control group in every time(P<0.05 ......

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