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Ⅱ型糖尿病患者尿微量白蛋白排出与下肢血管病变的关系
http://www.100md.com 《河北医学杂志》 2005年第10期
糖尿病,,糖尿病;白蛋白;下肢血管病变,1对象与方法,2结果,3讨论,参考文献:
     摘要:目的:探讨Ⅱ型糖尿病患者尿蛋白排出量与下肢血管病变的关系。方法:采用高分辨率的彩超测量伴有不同程度白蛋白尿的Ⅱ型糖尿病患者股总动脉内膜—中层厚度(简称IMT值),扫查下肢动脉。选择45例糖尿病人分为三个亚组,尿微量白蛋白正常者为DM-A组,尿微量白蛋白组为DM-B组,大量蛋白尿组为DM-C组。另选择15例正常人作为正常对照组即D组。结果:伴微量白蛋白尿及明显蛋白尿的糖尿病病人其股总动脉IMT值大于尿白蛋白正常的糖尿病病人(分别为左:0.95±0.11mmvs0.82±0.12mm 右0.94±0.12 mm vs0.81±0.10mm,p<0.01左0.99±0.12mmvs0.82±0.1mm,右0.97±0.18mmvs0.81±0.10mm ,p<0.01),尿蛋白正常的糖尿病人IMT值大于正常对照组(左:0.82±0.12 mm vs0.69±0.11 mm 右0.81±0.10 mm vs0.70±0.12 mm,p<0.01)。多因素回归分析表明,2型糖尿病IMT增厚的危险因素与糖尿病的病程、总胆固醇水平、血压、尿微量白蛋白的排出相关。结论:伴白蛋白尿的糖尿病患者存在下肢大血管病变。

    关键词:糖尿病;白蛋白;下肢血管病变

    The Relationship Between Microalbuminuria and Atherosclerotic Vascular Disease of the Lower Limb in Type Ⅱ Diabetes

    FENG Ai-ping,SHI Yun,LI Zhi-fen,et al

    (Mineral Hospital of Zaozhuang, Shandong Zaozhuang 277101, China)

    Abstract:Objective:To investigate the associations between microalbuminuria and early atherosclerosis of the lower limb in type 2 diabetes. Method: We measured the combined intima-media thickness (IMT) of the common femoralis arteries with high resolution ultrasound in 45 type 2 diabetic patients,and compared with 15 age-matched non-diabetics as control.The diabetic patients were subgrouped into A subjects whose urinary albumin excretion were normal , and B subjects who were with microalbuminuria,and C subjects who with macroalbuminuria.Result:The results showed that the IMT values were greater in diabetic patients than in control subjects(左:0.82±0.12 mm vs0.69±0.11 mm,右0.81±0.10 mm vs0.70±0.12 mm ......

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