布洛芬骨架型缓释微丸的研制
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崔久锋，唐 星，丁婉萍
(沈阳药科大学 药学院，辽宁 沈阳 110016)
摘要： 目的 制备布洛芬缓释微丸并优化其处方与工艺。方法 以圆整度和释放度为评价指标，分别对工艺因素(挤出速度、滚圆速度及滚圆时间) 和处方因素(微晶纤维素与低取代羟丙基纤维素的比例、润湿剂的用量) 进行单因素考察，在单因素考察的基础上进行正交优化试验，确定布洛芬骨架缓释微丸的处方工艺。结果 优化条件所得微丸外观圆整，粒子大小分布均匀，具有明显的缓释特性。结论 该方法可行、通过以上处方和工艺可以制备无需包衣的骨架型缓释微丸。
关键词：药剂学；骨架型缓释微丸；挤出滚圆法；布洛芬
中图分类号：R94 文献标识码：A
Preparation of ibuprofen sustained-release pellets by extrusion- spheronisation
CUI Jiu-feng , TANG Xing，DING Wan-ping
(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016 , China)
Abstract : Objective To prepare sustained-release pellets by extrusion-spheronisation with the material of microcrystalline cellulose and low substituted hydroxypropyl cellulose. Methods Taking roundness and dissolution as index, the effects of process variables and formulation variables on pellets preparation were investigated. Orthogonal design were used to optimize the experiment conditions. The formulation and preparation process of ibuprofen matrix sustained-release pellets were optimized. Results Pellets with good sphericity and appropriate particle distribution were optimized. The results show the pellets have a marked sustained release property. Conclusions It is possible to prepare matrix sustained-release pellets by extrusion-spheronisation with microcrystalline cellulose and low substituted hydroxypropyl cellulose without the need to coat the pellets.
Key words: pharmceutics; matrix sustained-release pellets; extrusion-spheronisation; ibuprofen
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