配体组装的促肝细胞生长素冻干脂质体靶向性及初步药效学
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姜爱萍1，王思玲1，程立华1，苏德森1，张景海2
(1.沈阳药科大学 药学院，辽宁 沈阳 110016； 2. 沈阳药科大学 制药工程学院，辽宁 沈阳 110016)
摘要：目的 利用自制的配体组装于促肝细胞生长素(PHGF)冻干脂质体的表面，考察其体内靶向性及初步药效学。方法 采用干燥重建法制备两种PHGF冻干脂质体，并对其进行荧光标记，利用冷冻切片技术对其体内靶向性与给药后肝组织形态的变化进行研究。结果 干燥重建法制备的PHGF脂质体PHGF包裹率约在40%(w)。连接有配体的PHGF冻干脂质体在肝中的荧光强度明显高于对照脂质体，而且此脂质体对CCl4引起的肝损伤有明显的修复作用。结论 包裹自制配体的PHGF冻干脂质体有显著的肝靶向性，并且是一种有效的治疗肝系列疾病的新剂型。
关键词：药剂学；药效学；靶向性；切片；促肝细胞生长素；冻干脂质体
中图分类号：R94 文献标识码：A
Targeting and primary pharmacology of PHGF liposomes by a freeze-drying method
JIANG Ai-ping 1, WANG Si-ling 1, CHENG Li-hua 1, SU De-sen 1, ZHANG Jing-hai 2
(1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China)
Abstract: Objective To investigate targeting and primary pharmacology of freeze-drying liposomes of PHGF assembling a kind of ligand synthesized by ourselves in vivo. Methods Two kinds of freeze-drying liposomes of PHGF were made by a dried-reconstituted vesicles method and labeled by a fluorescent probe ......
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