盐酸文拉法辛渗透泵控释片衣膜处方的研究
http://www.100md.com
| 第1页 |
参见附件(102KB，4页)。
李 威，潘卫三，王东凯
(沈阳药科大学 药学院， 辽宁 沈阳 110016)
摘要：目的 研究盐酸文拉法辛渗透泵控释片衣膜的最佳处方。方法 利用正交设计优化处方，根据不同时间累积释放度考察药物的释放情况。结果 所得衣膜的优化处方为：包衣材料为醋酸纤维素，增塑剂为PEG‐1500，增塑剂用量为20%，衣膜厚度(以片芯增重表示)为5%。结论 以优化处方包衣的渗透泵控释片，在10 h内呈现良好的零级释放特征。
关键词：药剂学; 渗透泵控释片; 衣膜处方; 正交设计; 盐酸文拉法辛
中图分类号：R 944；R 451 文献标识码：A
Study on the coating formulation of venlafaxine hydrochloride osmotic pump controlled release tablets
LI Wei, PAN Wei-san, WANG Dong-kai
(School of Pharmacy, Shenyang Pharmaceutical University ,Shenyang 110016,China)
Abstract: Objective To choose the optimum coating formulation of venlafaxine hydrochloride osmotic pump controlled release tablets.Method The optimal formulation was selected by the orthogonal design.Results The content of PEG-1500 in the optimal formulation is 20 %, and cellulose acetate is used for coating, meanwhile, tablet weight gain is 4 %.Conclusion The release profile of this formulation fits to zero-order release mechanism during first 10 h.
Keywords: pharmaceutics; osmotic pump controlled release tablets; coating formulation; orthogonal design; venlafaxine hydrochloride
您现在查看是摘要介绍页，详见PDF附件(102KB，4页)。