阿霉素脂质体的研究进展
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文章编号：(2004)03-0067-06,阿霉素脂质体的研究进展
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胡会国，邓意辉, 毕殿洲 (沈阳药科大学药学院，辽宁 沈阳 110016)
摘要：目的 综述阿霉素脂质体的研究进展。方法 依据近年来国内外文献资料，对新型阿霉素脂质体——温度敏感脂质体、免疫脂质体以及空间稳定脂质体进行概括，并在药效学上与传统阿霉素脂质体及阿霉素普通制剂进行比较。结果 新型阿霉素脂质体与传统阿霉素脂质体或阿霉素普通制剂相比，体内靶向性增强，抗肿瘤效果显著提高。结论 新型阿霉素脂质体有广阔的临床应用前景。
关键词 ：药剂学；研究进展；综述；阿霉素脂质体；体内靶向性
中图分类号：R 94 文献标识码：A
Research progress on doxorubicin liposome
HU Hui-guo, DENG Yi-hui, BI Dian-zhou
(School of Pharmacy , Shenyang Pharmacutical University , Shenyang 110016, China)
Abstract: Objective To review the development of doxorubicin (DR) liposome . Methods According to the related literatures published recently, the new type liposomes including thermo-sensitive liposome, immunoliposome, sterically stabilized liposome were introduced respectively, comparing with the traditional DR liposome and the ordinary DR preparation. Results The new type liposomes of DR can enhance the targeting action and improve the effectively of anticancer drug markedly. Conclusions The new type liposomes of DR have promising future for clinical application.
Key words: pharmaceutics; liposome; review; doxorubicin; targeting action
胡会国，邓意辉, 毕殿洲 (沈阳药科大学药学院，辽宁 沈阳 110016)
摘要：目的 综述阿霉素脂质体的研究进展。方法 依据近年来国内外文献资料，对新型阿霉素脂质体——温度敏感脂质体、免疫脂质体以及空间稳定脂质体进行概括，并在药效学上与传统阿霉素脂质体及阿霉素普通制剂进行比较。结果 新型阿霉素脂质体与传统阿霉素脂质体或阿霉素普通制剂相比，体内靶向性增强，抗肿瘤效果显著提高。结论 新型阿霉素脂质体有广阔的临床应用前景。
关键词 ：药剂学；研究进展；综述；阿霉素脂质体；体内靶向性
中图分类号：R 94 文献标识码：A
Research progress on doxorubicin liposome
HU Hui-guo, DENG Yi-hui, BI Dian-zhou
(School of Pharmacy , Shenyang Pharmacutical University , Shenyang 110016, China)
Abstract: Objective To review the development of doxorubicin (DR) liposome . Methods According to the related literatures published recently, the new type liposomes including thermo-sensitive liposome, immunoliposome, sterically stabilized liposome were introduced respectively, comparing with the traditional DR liposome and the ordinary DR preparation. Results The new type liposomes of DR can enhance the targeting action and improve the effectively of anticancer drug markedly. Conclusions The new type liposomes of DR have promising future for clinical application.
Key words: pharmaceutics; liposome; review; doxorubicin; targeting action
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