【摘要】 目的 探讨上消化道出血患者的Ⅰ型幽门螺杆菌感染状况。方法 对341例上消化道出血患者行胃镜检查，ELISA法测定患者血清幽门螺杆菌(Hp) CagA 和 VacA抗体进行毒株分型。结果 上消化道出血患者的Ⅰ型幽门螺杆菌检出率70.09%(239/341)。胃溃疡71.43%(40/56)，十二指肠溃疡80.22%(146/182)，胃癌78.57%(11/14)与急性胃粘膜病变Ⅰ型幽门螺杆菌检出率44.90%(22/49)相比差异有显著性(P<0.001，P<0.001，P<0.05)。结论 上消化道出血患者的Ⅰ型幽门螺杆菌感染率高，胃、十二指肠溃疡、胃癌Ⅰ型幽门螺杆菌感染显著高于急性胃粘膜病变。

    关键词 上消化道出血 幽门螺杆菌 细胞毒素相关基因蛋白 空泡毒素

    Analysis of Helicobacter pylori types in patients with upper gastrointestinal hemorrhage

    Zheng Fashou,Fan Xiaoming,Liu Hongyan,et al.

    Department of gatroenterology,Jinshan Hospital,Fudan University,Shanghai 200540.

    【Abstract】 Objective To investigate prevalence of type Ⅰ Helicobacter pylori in patients with upper gastrointestinal hemorrhage.Methods 341 patients with upper gastrointestinal hemorrhage undergoing upper gastrointestinal endoscopy were tested for serum anti-H. pylori antibody classified as typeⅠ,typeⅡ ......