降粘、抗凝药物治疗2型糖尿病血液流变学指标的变化
降粘,,2型糖尿病;,降粘、抗凝药;,血液流变学指标;,血糖,1资料与方法,2结果,3讨论,参考文献
摘要: 目的：探讨降粘、抗凝药物蚓激酶、血塞通对2型糖尿病患者血糖及各项血液流变学指标的影响。方法： 180例2型糖尿病患者随机分为对照组及蚓激酶、血塞通、蚓激酶+血塞通3个治疗组，测定各组的空腹及3餐后2 h血糖,并测定3个治疗组治疗前后的高切、低切全血粘度及血浆粘度、红细胞压积、纤维蛋白原5项血液流变学指标。结果：蚓激酶、血塞通、蚓激酶+血塞通3个治疗组空腹及3餐后2 h血糖均明显低于对照组(P<0.05～0.01)，3个治疗组治疗后高切、低切全血粘度及血浆粘度、红细胞压积、纤维蛋白原均明显低于治疗前(P<0.05～0.01)。结论：降粘、抗凝药物蚓激酶、血塞通单独或联合应用均可改善2型糖尿病患者血液流变学障碍，促进血糖控制。关键词: 2型糖尿病; 降粘、抗凝药; 血液流变学指标; 血糖
Changes of hemorrheology parameters of type 2 diabetes mellitus with antiagglutinate drugs
LI Xiaolan, ZHANG Lei, XU Jianhua
(Department of Endocrinology, Fifth Affiliated Hospital, Xinjiang Medical University,Urumqi 830011, China)
Abstract: Objective: To investigate the effect of indexes of hemorrheology and BG in type 2 diabetes mellitus patients with using antiagglutinate drugs: Lumrolcinase and Xuesaitong. Methods: The one hundred and eighty patients were randomly divided into four groups: control group, Lumrolcinase group, Xuesaitong group, Lumrolcinase and Xuesaitong group. To examinate FBG and 2 h BG in all four groups. To examinate blood viscosity, plasma viscosity, HCT and FIB before and after treatment in three treating groups. Results: FBG and 2 h BG in treating groups were lower than control group (P<0.05~0.01). Blood viscosity, plasma viscosity, HCT and FIB in treating groups were lower than before treatment (P<0.05~0.01). Conclusion: antiagglutinate drugs can improve condition of hemorrheology and enhance to control the BG. ......
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