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脂肪肝患者载脂蛋白B、CⅢ、E基因多态性对血脂水平影响的研究
http://www.100md.com 《新疆医科大学学报》 2005年第7期
脂肪肝,,脂肪肝;载脂蛋白;基因多态性,1材料与方法,2结果,3讨论,参考文献:
     摘要: 目的: 探讨脂肪肝患者载脂蛋白B、CⅢ、E基因多态性与血脂的关系。 方法: 采用基因芯片技术对118例脂肪肝患者进行了载脂蛋白B、CⅢ、E的基因多态性位点分析,并测定其血脂等血生化指标。结果: 载脂蛋白B、CⅢ、E 3种基因各多态性位点与所选择血生化指标变化无明显关联(P>0.05)。结论:可能载脂蛋白B、CⅢ、E基因多态性并不影响脂肪肝患者的血脂水平。

    关键词: 脂肪肝;载脂蛋白;基因多态性

    apolipoprotein B, CⅢ, E gene polymorphisms and lipids metabolism disorders of fatty liver patients

    YAO Hua, XU Feili, ZhU Bin, et al

    (Affiliated Traditional Chinese Medicine Hospital, Xinjiang Medical University, Urumqi 830000, China)Abstract: Objective: To investigate the relationship of serum biochemicals and apolipoprotein B, CⅢ, E gene polymorphisms in fatty liver. Method: The genetic polymorphisms of apolipoprotein B, CⅢ, E were determined by the technique of oligonucleotide arrays (DNA chips) among 118 cases with fatty liver and fasting serum biochemicals were also measured in these cases. Result: There was no significant difference in Serum biochemicals among different genotypes of apolipoprotein B, CⅢ, E genes in fatty liver. Conclusion: It suggested that genetic polymorphisms of apolipoprotein B, CⅢ, E had no effects on lipids disorders of fatty liver. ......

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