急性冠状动脉综合征患者血清内皮素、一氧化氮水平的变化
冠状,,急性冠状动脉综合征；,内皮素；,一氧化氮；,卡托普利,1资料与方法,2结果,3讨论,参考文献:
摘要: 目的： 探讨急性冠状动脉综合征(ACS)患者血清内皮素(ET)、一氧化氮(NO)水平变化的临床意义及卡托普利干预的效果。方法： 120例ACS患者中急性心肌梗死(AMI)60例(服用和未服用卡托普利各30例)，不稳定心绞痛(UA)60例(服用和未服用卡托普利各30例)，采用放射免疫法和化学比色法测定了120例ACS患者和30例正常对照组的血清ET、NO水平，并对各组进行了比较。结果：(1)ACS患者血清ET水平明显高于正常对照组,NO水平明显低于正常对照组(P<0.01～0.001)，尤其是AMI患者更为明显；(2)AMI和UA组常规治疗后ET水平明显下降，NO水平明显回升(P<0.01～0.001)，且2组的服用卡托普利组较未服用卡托普利组更为明显，差异有统计学意义(P<0.05)。结论： ACS时ET、NO水平的变化可能在ACS发病过程中起着一定的作用，而该作用通过卡托普利干预可得到缓解。关键词： 急性冠状动脉综合征； 内皮素； 一氧化氮； 卡托普利
The significance of the change of levels of endotheline and nitric oxide inserum of the patients with acute coronary syndrome
XING Hongyun， WANG Yongzhi， WANG Yan
(Department of Cardiology, Fifth Affiliated Hospital, Xinjiang Medical University,Urumqi 830011, China)
Abstract: Objective: Explore the clinic significance of the change of levels of endotheline (ET) and nitric oxide (NO) in serum of the patients with acute coronary syndrome (ACS) and the effect of the involvement in captopril. Methods: There were 60 cases with acute myocardial infarction (AMI) among 120 ACS subjects, 30 subjects took the captoril, the other 30 subjects did not take captoril. Meanwhile, there were 60 cases with unstable angina pectoris (UA) among the 120 ACS, too. 30 subjects took captoril, the other 30 subjects did not take captoril. Using colorimetry and methods in radiation immunity to measure the level of ET and NO in serum of 120 subjects with ACS and 30 subjects normal people around the therapy,then compared them. Results: (1) The level of ET in blood of the patients with ACS was higher than that of normal obviously, and the level of NO was lower than that of normal obveriously (P<0.01～0.001), the change in patients with AMI was especially obvious. The level of ET of patients with AMI and UA decreased obviously after therapy,but the level of NO rose again obviously (P<0.01～0.001), meanwhile, the two group taking captopril changed more obviously than the group without taking captopril, the difference had statistical significance (P<0.05). Conclusion: The level changes of ET and NO of patients with ACS may play an important role on the course of pathogenesis of ACS, which can relieve by the involvement of captopril. ......
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