肿瘤标志物_____宫颈癌；肿瘤标志物；辅助诊断

5种肿瘤标志物在宫颈癌检测中的信息提示和临床应用

http://www.100md.com 《新疆医科大学学报》 2005年第2期

肿瘤标志物,,宫颈癌；肿瘤标志物；辅助诊断,1研究对象与方法,2结果,3讨论,参考文献：

     摘要：目的：鳞状上皮细胞癌抗原(SCC)、癌胚抗原(CEA)、细胞角质素19(CYFRA211)、癌抗原125(CA125)、糖链抗原199(CA199)在宫颈癌检测中的信息提示和临床应用价值。方法：本组107例，分为3组，宫颈癌组63例，宫颈上皮内瘤变(CIN)组16例，正常对照组28例，采用放射免疫分析法检测3组的血清CA125、CA199和CYFRA211水平，并采用酶联免疫吸附法检测血清SCC、CEA水平。结果：(1)宫颈癌组CYFRA211、SCC水平高于CIN组和正常对照组，差异有统计学意义(P<0.05)。(2)宫颈癌组CYFRA211、SCC、CEA阳性检出率随临床分期进展增高，Ⅱ期、Ⅲ/Ⅳ期与Ⅰ期比较差异有统计学意义(P<0.05)。CA199、SCC和CEA阳性检出率随分化程度增高而降低，高分化与低分化比较差异有统计学意义(P<0.05)。宫颈腺癌CA125、CA199阳性检出率高于鳞癌(P<0.05)，宫颈鳞癌SCC阳性检出率高于腺癌(P<0.05),CYFRA211+SCC+CA199联合检测可提高宫颈癌的检出率。结论：5种肿瘤标志物在宫颈癌患者血清中均有阳性分布，其中CYFRA211和SCC对宫颈癌患者的辅助诊断、病情估计具有较高的临床价值。

    关键词: 宫颈癌；肿瘤标志物；辅助诊断

    Investigation of the clinical value of five tumor markers in cervical cancer

    LEI Jun, ZHANG Tong, CHEN Hongming

    (Department of Oncology, Affiliated Traditional Chinese Medicine Hospital,Xinjiang Medical University, Urumqi 830000, China)

    Abstract: Objectives: To investigate the clinical value of the serum levels of cancer antigen 125 (CA125), carbohydrate antigen 199 (CA199), cytokeratin19fragments (CYFRA211), squamous cell carcinoma antigen (SCC) and carcinoembryonic antigen (CEA) in patients with cervical cancer. Methods: CA125, CA199 and CYFRA211 were measured by immunoradiometric assay, SCC and CEA were measured by enzymelinked immunosorbent assay. Twentyeight healthy females, 16 cervical intraepithelial neoplasia and 63 patients with cervical cancer were detected. Results: The levels of CYFRA211 and SCC in cervical cancer were significantly higher than that of healthy females and cervical intraepithelial neoplasia(P<0.05). The positive rate of CYFRA211, SCC and CEA in patients with cervical cancer increased with advance of the clinical stages (P<0.05). The positive rates of CYFRA211 and SCC were different with histological differentiation. The positive rate of CA125 and CA199 were found significantly higher among patients with adenocarcinoma than those with squamous cell carcinoma. The sensitivity and utility can be increased with combination of CYFRA211+SCC+CA199 in diagnosis of cervical cancer.Conclusions: These five tumor markers can be detected in patients with cervical cancer, there are specifically clinical application value of CYFRA211 and SCC for diagnosis and monitoring the progress of the disease. ......

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