妊娠期高血压疾病_

sICAM1与妊娠期高血压疾病发病的关系

http://www.100md.com 《新疆医科大学学报》 2005年第1期

妊娠期高血压疾病,,妊娠；妊娠期高血压疾病；可溶性细胞间粘附分子,1资料和方法,2结果,3讨论,参考文献:

     摘要: 目的：探讨可溶性细胞间粘附分子(sICAM1)与妊娠期高血压疾病发病的关系，并分析汉族与维吾尔族(维族)孕妇血清sICAM1的含量有无异同。方法: 采用双抗体夹心ELISA法分别测定妊娠期高血压疾病组(研究组)及对照组血清中sICAM1的含量。结果: (1)研究组sICAM1 含量(4.834±1.022) pg/ml,明显高于对照组(4.266±1.115) pg/ml，差异有统计学意义(t=2.431, P<0.05)； (2)子痫前期轻度、重度及子痫患者血清sICAM1的含量差异无统计学意义；(3)汉族与维族孕妇血清sICAM1的含量差异无统计学意义。结论: (1)妊娠晚期血清sICAM1的升高可能是妊娠期高血压疾病的发病原因之一；(2)血清sICAM1的含量与族别无关。

    关键词：妊娠；妊娠期高血压疾病；可溶性细胞间粘附分子

    The effects of sICAM1 on hypertensive disorder complicating pregnancy

    CAI Xia, GENG Lihong, ZHANG Yaoxin，et al

    (Department of Obstetrics and Gynecology, First Affiliated Hospital, Xinjiang Medical University,Urumqi 830054, China)

    Abstract: Objective: To investigate the effect of sICAM1 on hypertensive disorder complicating pregnancy. Methods: The level of sICAM1 in serum in hypertensive disorder complicating pregnancy group and control group were tested with double antibody ELISE. Result: (1) The level sICAM1 in hypertensive disorder complicating pregnancy group was (4.834±1.022) pg/ml, higher than (4.266±1.115) pg/ml on control group (P<0.05)； (2) There was no difference between preeclampsia and eclampsia； (3) There was no difference between Han and Uigur on the level of sICAM1 in the third trimester. Conclusion: (1) The higher sICAM1 lever in serum could be thought as one of reasons of hypertensive disorder complicating pregnancy. (2) The sICA1 lever has not relation with nationality. ......

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