Fos蛋白_____急性胃炎；Fos蛋白；中枢神经系统

乙醇诱导大鼠急性胃炎后Fos在中枢神经系统的表达

http://www.100md.com 《新疆医科大学学报》 2005年第4期

Fos蛋白,,急性胃炎；Fos蛋白；中枢神经系统,1材料和方法,2结果,3讨论,参考文献:

     摘要: 目的：探讨乙醇诱导大鼠急性胃炎后Fos在中枢神经系统的表达及其意义。方法：取30只成年雄性Wistar大鼠，随机分为5组，每组6只。A组：单纯生理盐水灌胃组;B组：单纯乙醇灌胃组；C组：膈下迷走神经切断乙醇灌胃组；D组：内脏大、小神经切断乙醇灌胃组；E组：膈下迷走神经和内脏大、小神经均切断乙醇灌胃组。运用免疫组化技术显示Fos阳性神经元在大鼠中枢神经系统(CNS)中的分布。结果： B、C组动物的Fos阳性神经元在丘脑腹后外侧核、第9胸髓后角胶状质内大量存在,疑核和迷走神经背核内有少量聚集；B、D组Fos阳性神经元在疑核和迷走神经背核内有较多聚集，但远低于B、C组在丘脑腹后外侧核、第9胸髓后角胶状质内的Fos阳性神经元数。而A、E组在上述4个核团内Fos阳性神经元则较少。结论：胃的痛觉冲动以交感神经传入为主。

    关键词：急性胃炎；Fos蛋白；中枢神经系统

    Expression of Fos in central nevrous system after ethanolinduced acute gastritis in rat

    GAN Ziming， LIU Jun， CHEN Shengguo， et al

    (Department of Human Anatomy, Xinjiang Medical University, Urumqi 830054, China)

    Abstract: Objective: To study the expression and significance of cfos in central nervous system after ethanolinduced acute gastritis in rat. Methods: Animals were randomly classified into 5 groups: group A, gasterpoured by physiological solution; group B, gasterpoured by ethanol; group C, gasterpoured by ethanol after hypophrenic vagectomy; group D, gasterpoured by ethanol after bigsmall splanchnicotomy; group E, gasterpoured by ethanol after hypophrenic vagotomy and bigsmall splanchnicotomy.The distribution of cfos positive neuron in central nervous system was displayed and immunohistochemical staining method was used. Results: There were a lot of cfospositive neuron in thalamus ventrallateral nucleus and No 9 thoracic medullaris posterior horn cinerea in groups B and C; Fos positive neuron in ambiguous nucleus and dorsal nucleus of vagus nerve were better in groups B and D, but they were obiviously less than them of halamus ventrallateral nucleus and No 9 thoracic medullaris posterior horncinerea in groups B and C. Conclusion: The gastric algesia impulsion are mainly conducted by sympathetic afferent nerve. ......

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