新疆_____HLADR;_变应性鼻炎;

HLADR1、3、15与新疆地区人群变应性鼻炎的关联分析

http://www.100md.com 《新疆医科大学学报》 2005年第5期

新疆,,HLADR;,变应性鼻炎;,聚合酶链反应,1材料与方法,2结果,3讨论,参考文献:

     摘要: 目的: 研究人类主要组织相容性复合体HLADR1、3、15等位基因在新疆地区人群变应性鼻炎(Allergic rhinitis, AR)中的表达及意义。方法: 采用聚合酶链反应序列特异性引物(PCRssp)技术对42例新疆地区变应性鼻炎患者(AR组)的HLADR1、3、15等位基因进行检测，另选择同地区45例体检健康者(对照组)进行对照研究。结果: 变应性鼻炎组携带HLADR1、3、15等位基因的频率分别为10.71%、0%、21.42%,对照组分别为1.11%、3.33%、4.44%。两组携带HLADR1、15等位基因的频率差异有统计学意义(P<0.05)(比数比分别12.00和7.69。)。结论: HLADR1和HLADR15等位基因是新疆地区人群中变应性鼻炎重要危险基因。

    关键词: HLADR; 变应性鼻炎; 聚合酶链反应

    he association between the feature of allergic rhinitis and HLADR1,3,15 genesLIU Xueli, ZHANG Tong, XIANG Yangbin

    (Department of Pathogenetic, Xinjiang Medical University, Urumqi 830054, China)Abstract: Objective: To study the association between the feature of allergic rhinitis (AR) and HLADR1、3、15 genes among a xinjiang population of the han nationality. Methods: HLADR1、3、15 alleles were conducted in 42 patients with allergic rhinitis and 45 normal controls from xinjiang with Polymerase Chain Reactionsequence specific primer(PCRssp). Results: The frequency of HLADR1and HLADR15 (10.71%,21.42%) was higher in AR than that in normal healthy controls(1.11%,4.44%) (P<0.05). Conclusion: Patients with AR is associated with high frequency of HLADR1 and HLADR 15. ......

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