CyclinD1_

CyclinD1、TGFβ1、GSTπ在食管鳞癌组织中的表达和意义

http://www.100md.com 《新疆医科大学学报》 2005年第4期

CyclinD1,,食管鳞癌；CyclinD1；TGFβ1；GSTπ；免疫组织化学,1材料与方法,2结果,3讨论,参考文献:

     摘要: 目的：研究细胞周期蛋白D1(CyclinD1)、转化生长因子β1 (TGFβ1)、胎盘型谷胱甘肽硫转移酶(GSTπ)在食管鳞癌及正常食管组织中的表达，探讨其与食管鳞癌发生、发展及转移的关系。方法：采用免疫组织化学法，对81例食管鳞癌组织和43例正常食管组织CyclinD1、TGFβ1、GSTπ的表达进行检测。结果：食管鳞癌和正常食管组织中CyclinD1、TGFβ1和GSTπ的阳性表达差异均有统计学意义(P<0.05)，3者在伴有和不伴有淋巴结转移癌组织的阳性表达差异均无统计学意义(P>0.05)。CyclinD1和TGFβ1随食管鳞癌组织分化程度的降低其表达增强，但其表达与组织分型比较差异无统计学意义，GSTπ随着食管鳞癌组织分化程度的降低表达减弱。结论：CyclinD1、TGFβ1可能与食管鳞癌的发生、恶性程度有关，GSTπ在诊断早期癌方面具有一定的意义。CyclinD1、TGFβ1、GSTπ可作为对食管鳞癌的诊断指标，尤其是GSTπ对食管鳞癌早期诊断有一定的参考价值。

    关键词：食管鳞癌；CyclinD1；TGFβ1；GSTπ；免疫组织化学

    The expressions and significance of CyclinD1, TGFβ1 and GSTπ in human squamous cell carcinoma of esophagus

    WU Jiang, LIU Cun

    (Department of Endoscopy, Second Affiliated Hospital, Xinjiang Medical University,Urumqi 830028, China)

    Abstract: Objective: To study the expressions of CyclinD1, TGFβ1 and GSTπ in squamous cell carcinoma of esophagus, and their effects on the growth of human squamous cell carcinoma of esophagus. Methods: Eightyone specimens of human squamous cell carcinoma of esophagus and 43 normal esophagus as control were assessed by immunohistochemical method (SP method). Result: The positive expression rate of CyclinD1, TGFβ1 and GSTπ in squamous cell carcinoma of esophagus was higher than that in normal esophagus. The positive expression rate of CyclinD1, TGFβ1 and GSTπ were higher by lymphatic metastasis grades than no lymphatic metastasis grades. Conclusion: CyclinD1, TGFβ1 and GSTπ have more significant differences in squamous cell carcinoma of esophagus than normal esophagus.They play an important role in development of squamous cell carcinoma of esophagus. They would be helpful in diagnosis of squamous cell carcinoma of esophagus, especially GSTπ may act as an early maker. ......

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