各型肝炎患者中输血传播病毒感染的检测及临床意义
输血传播病毒,,输血传播病毒；肝炎；聚合酶链式反应,1材料与方法,2结果,3讨论,参考文献：
摘要： 目的：了解输血传播病毒(TTV)在各型肝炎患者中的感染情况。 方法：采用套式PCR方法，对218例不同型别的肝炎病人血清进行TTV DNA检测。结果：218例不同肝炎病人中共检出72例TTVDNA阳性血清，总检出率为33.0%，不同民族、性别间TTVDNA 阳性率差异无统计学意义(P>0.05)。其中排除非甲非戊型肝炎单纯转氨酶增高病人中TTVDNA阳性率为53.9%，而在明确诊断为甲型、乙型、丙型肝炎病人中TTVDNA阳性率为26.5%，两组相比差异有统计学意义(χ2=13.38, P<0.05)。结论：各型肝炎患者中存在TTV感染，非甲非戊型肝炎单纯转氨酶增高病人中TTV感染率明显高于明确病原肝炎病人。TTV感染与肝炎有关，可能是原因不明肝炎的病因之一。关键词： 输血传播病毒；肝炎；聚合酶链式反应
Dectection of TTV in hepatitis patients
MA Xiumin, Amanguli, XIAO Lin, et al
(Department of Pathogenic Biology, Xinjiang Medical University, Urumqi 830054, China)
Abstract： Objective： To study the prevalence of transfusion transmitted virus (TTV) in hepatitis patients. Methods：Sera from hepatitis patients were tested by nested polymerase chain reaction (nPCR) assay for the presence of TTVDNA. Results：The total detection rate of TTVDNA in those 218 objects was 33.0%. The TTV positive rate was 53.9% in non AE hepatitis, but 26.5 % in hepatitis patients whose diagnosis were clear. There was no relationship between TTV infection with nationalities、sex of hepatitis patients. Conclusion： TTV infection may be one of the cause of non AE hepatitis. ......
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