疫诱导的 HBV特异性体液免疫应答 ,而且能在未发

    生 Th1P Th2型免疫应答偏移的前提下提高了 HBV

    特异性细胞免疫应答水平 ,这不仅为增强基因免疫

    诱导的特异性体液和细胞免疫应答提供一个新的技

    术平台 ,也为增强乙型肝炎治疗性基因疫苗的免疫

    应答水平提供新的策略。

    4 参考文献

    1 Beckebaum S , Cicinnati VR , Gerken G 1 DNA2based immunotherapy :

    potential for treatment of chronic viral hepatitis J . Rev Med Virol ,2002 ; 12(5) : 297.

    2 Martins L P , Lau L L , Asona M S et al . DNA vaccination against per2

    sistent viral infectionJ . J Virol , 1995 ; 69 (4) : 2684.

    3 Mitchell J A , Green T D , Bright R A et al . Induction of heterosubtypic

    immunity to influenza A virus using a DNA vaccine expressing hemagglu2

    tinin2C3d fusion proteins J . Vaccine , 2003 ; 21 :902.

    4 Test S T , Mitsuyoshi J , Connolly C C et al . Increased immunogenicity

    and induction of class switching by conjugation of complement C3d to

    pneumococcal serotype 14 capsular polysaccharide J . Infection and Im 2

    munity , 2001 ; 69 (5) : 3031.

    5 Ross TM, Xu Y, Bright R A et al . C3d enhancement of antibodies to

    Hemagglutinin accelerates protection against influenza virus challenge ......