冠心病__(论著)

冠心病患者血清TBIL与OX-LDL水平的变化及其相关性

http://www.100md.com 《中国热带医学杂志》 2005年第2期

冠心病,,冠心病；胆红素；脂蛋白；氧化修饰低密度脂蛋白；血红素氧化酶,1材料和方法,2结果,3讨论,参考文献：

     摘要：目的探讨冠心病(Coronary heart disease, CHD)患者血清总胆红素(Total bilirubin, TBIL)与氧化修饰低密度脂蛋白(low density lipoprotein, OX-LDL)水平的变化及其相互关系。方法采用氧化酶法和ELISA(Enzyme-linked immunoadsordent assay)法分别检测血清TBIL及血浆OX-LDL水平。结果冠心病患者血清TBIL水平显著低于正常对照组(P<001)，而血浆OX-LDL水平则明显高于正常对照组(P<001); 冠心病患者血清TBIL与血浆OX-LDL水平呈显著负相关(r =-059, P<001)，而正常对照组这两成分间则无明显相关性(r =-018，P<005)。结论冠心病患者血清TBIL水平显著降低而OX-LDL显著升高；冠心病患者血清TBIL抗LDL氧化能力的减弱可能是导致OX-LDL升高的重要原因之一。

    关键词：冠心病；胆红素；脂蛋白；氧化修饰低密度脂蛋白；血红素氧化酶

    中图分类号：R5414 文献标识码：A 文章编号：1009-9727(2005)02-203-02

    Study on the relationship between total bilirubin and oxidized low density lipoprotein in patients with coronary heart disease YI Wei-lian, YUAN Han-rao, CHEN Ling, et al (laboratory Department of Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, P R China)

    Abstract：Objective To investigate the changes of total biliruin (TBIL) and oxidized low density lipoprotein (OX-LDL) and the relationship in patients with coronary heart disease(CHD) Methods Total bilirubin is measured by analysis Plasma OX-LDL was measured by double antibody enzyme-linked immunoadsordent assay Results Serum level of TBIL is greatly decreased in patients with CHD as compared with healthy subjects(P<001), while plasma level of OX-LDL is markedly increased in patients with CHD as compared with healthy subjects (P<001) Serum level of TBIL is inversely correlated with plasma level of OX-LDL in patients with CHD(r =-059, P<001) There is no difference in serum level of TBIL and plasma level of OX-LDL in healthy subjects Conclusion TBIL plays roles against LDL oxygenation in CHD and the impairment of anti-oxidate ability of TBIL may be an important factor causing OX-LDL level to be increased in patients with CHD ......

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