肺纤维化患者血清Ⅲ型前胶原和层粘连蛋白监测的临床意义
肺纤维,,Ⅲ型前胶原；层粘连蛋白；肺疾病，间质性,1对象与方法,2结果,3讨论,参考文献：
摘要：目的 探讨不同程度特发性间质性肺炎(IIP)患者血清Ⅲ型前胶原(PCⅢ)和层粘连蛋白(LN)浓度的相关性。 方法 对29名IIP患者进行呼吸困难程度、胸部影像学改变、通气功能、肺容量、弥散量、静息时肺泡气-动脉血氧分压差、运动后动脉血氧饱和度等7个方面检查后给出临床-影像-生理(CRP)评分，根据CRP评分系统将患者分为低分组、高分组，与健康对照同时测定血清PCⅢ和LN水平。 结果 CRP评分与Ⅲ型前胶原作等级相关分析(rs=05238，P<001)，二者呈正相关。血清Ⅲ型前胶原低分组与对照组无统计学差异(P=05823)，高分组与对照组有统计学差异(P<0001)，且高分组与低分组有统计学差异(P<001)。CRP评分与层粘连蛋白作等级相关，相关系数rs’=04227(001关键词：Ⅲ型前胶原；层粘连蛋白；肺疾病，间质性
中图分类号：R56313 文献标识码：A 文章编号：1009-9727(2005)02-215-03
Clinical significance of serum type Ⅲ procollagen peptide and laminin in idiopathic interstitial pneumonia and clinical response to treatment YANG Rui-sheng, XIE Hai-ying, ZENG Bi-juan (Songgan People’s Hospital of Shenzhen City, Shenzhen 518105, Guangdong, P R China)
Abstract：Objective To explore clinical relevance of serum type Ⅲ procollagen peptide and Laminin in idiopathic interstitial pneumonia Methods A composite clinical-radiographic-physiologic(CRP)scoring system was devised,using these 7 variables:dyspnea,chest radiogragh,spirometry,luμg volume,diffusion capacity,resting alveolar-arterial PO2,and exercise O2 saturation29 patients with idiopathic interstitial pneumonia were divided into 2 groups according to CRP scoring system:low score group,high score groupThe serum concentrations of type Ⅲ procollagen peptide (PCⅢ)and Laminin were measured in patients and the control group Result The CRP score determination correlated with the serum concentration of PCⅢ(r=05823,P<001)The PCⅢ of high scores group was significantly higher than that of control group(P<0001),and was significantly higher than that of low scores group(P<001),but the low scores group wasn’t higher than that of control group(P=05823)The CRP score showed a significant correlation with the concentration of LN(r=04247,P<005) Conclusion Serum concentrations of PCⅢ and LN in patients with idiopathic interstitial pneumonia are important and not-hurted index to evaluate with CRP scores system regarded as measure balance ......
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