载脂蛋白B基因多态性及血脂水平与慢性丙型肝炎的相关性
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李 雁, 刘正稳, 韩群英, 李 晗
慢性丙型肝炎;载脂蛋白B基因;多态性;血脂,李雁,刘正稳,韩群英,李晗,李雁,通讯作者:,Correlationsofchronichepat
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李雁, 刘正稳, 韩群英, 李晗, 西安交通大学医学院第一附属医院传染科 陕西省西安市 710061
李雁, 女, 1980-01-30生, 陕西省西安市人, 汉族, 2003年西安交通大学医学院临床医学专业本科毕业, 同年入母校攻读传染病学硕士学位, 主要从事病毒性传染病的研究.
国家自然科学基金资助项目, No.30170842
通讯作者: 刘正稳, 710061, 陕西省西安市健康路1号, 西安交通大学医学院第一附属医院传染科. Liuzhengwen@medmail.com.cn
电话: 029-85324066 传真: 029-85226360
收稿日期: 2005-11-08 接受日期: 2005-11-26
Correlations of chronic hepatitis C virus infection with Xba I polymorphism of apolipoprotein B gene and serum lipid metabolism
Yan Li, Zheng-Wen Liu, Qun-Ying Han, Han Li
Yan Li, Zheng-Wen Liu, Qun-Ying Han, Han Li, Department of Infectious Diseases, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Supported by National Natural Science Foundation of China, No.30170842
Correspondence to: Dr. Zheng-Wen Liu, Department of Infectious Diseases, the First Affiliated Hospital of Xi’an Jiaotong University, 1 Jiankang Road, Xi’an 710061, Shaanxi Province, China. Liuzhengwen@medmail.com.cn
Received: 2005-11-08 Accepted: 2005-11-26
Abstract
AIM: To investigate the Xba I locus polymorphisms of apolipoprotein B (Apo B) gene and their internal correlations with chronic hepatitis C virus infection and serum lipid metabolism.
METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to analyze the genotype of the Apo B gene in 77 patients and 62 controls, according to the design of case control study. Meanwhile, the blood samples were analyzed for hepatic function and serum lipid by automatic biochemistry analyzer.
RESULTS: The frequencies of X+X– and X–X– of Xba I locus polymorphism were different between the patients and the controls and the frequency of X+ allele in the patients was lower than that in the controls (0.071 vs 0.121, P = 0.136), but no statistical significance was not found ......
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