P 选择素 L-EGF 单抗对 SCID 小鼠胃癌转移抑制作用
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陈金联, 陈明祥, 陆金来, 陈维雄, 朱金水,
P选择素单克隆抗体;SCID小鼠;胃癌;转移,P选择素L-EGF单抗对SCID小鼠胃癌转移抑制作用,陈金联,陈明祥,陆金来,陈维雄,朱金水,陈尼维,陆允敏,周同,吴云林,陈国强,通讯作者:,In
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陈金联, 陈明祥, 陆金来, 陈维雄, 朱金水, 陈尼维, 陆允敏, 上海交通大学附属第六人民医院消化科 上海市 200233
周同, 吴云林, 上海交通大学附属瑞金医院 上海市 200025
陈国强, 中国科学院上海实验动物中心 上海市 200031
上海市卫生局面上基金资助课题, No. 034045
通讯作者: 陈金联, 200233, 上海市宜山路600号, 上海交通大学附属第六人民医院消化科. wqq_021002@163.com
电话: 021-64369181-8970
收稿日期: 2005-09-28 接受日期: 2005-10-08
Inhibition of P-selectin L-EGF monoclonal antibody on metastasis of human gastric carcinoma in severe combined immunodeficient mice
Jin-Lian Chen, Ming-Xiang Chen, Jin-Lai Lu, Wei-Xiong Chen, Jin-Shui Zhu, Ni-Wei Chen, Yun-Min Lu, Tong Zhou, Yun-Lin Wu, Guo-Qiang Chen
Jin-Lian Chen, Ming-Xiang Chen, Jin-Lai Lu, Wei-Xiong Chen, Jin-Shui Zhu, Ni-Wei Chen, Yun-Min Lu, Department of Gastroenterology, the Affiliated Shanghai Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai 200233, China
Tong Zhou, Yun-Lin Wu, the Affiliated Ruijin Hospital of Shanghai Jiaotong University, Shanghai 200025, China
Guo-Qiang Chen, Animal Center of Shanghai Laboratory, Chinese Academy of Sciences, Shanghai 200031, China
Supported by the Scientific Foundation of Shanghai Public Health Administration, No. 034045
Correspondence to: Jin-Lian Chen, Department of Gastroenterology, the Affiliated Shanghai Sixth People's Hospital of Shanghai Jiaotong University, Shanghai 200233, China. wqq_021002@163.com
Received: 2005-09-28 Accepted: 2005-10-08
Abstract
AIM: To investigate the role of cell adhesion molecule P-selectin L-EGF monoclonal antibody (L-EGF Mab) in the inhibition of the metastasis of gastric cancer in sev-ere combined immunodeficient (SCID) mice.
METHODS: Human gastric cancer cell line SGC-7901 was orthotopically implanted into SCID mice to estab-lish metastatic model. At the 3rd day after implantation, the mice were intravenously injected with normal saline (n = 11) or P-selectin L-EGF Mab (n = 9) ......
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