用体外释放实验优选伊曲康唑凝胶剂的处方
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李 飞1,于 淼1，马明欣2，王思玲2，苏德森2
(1.沈阳药科大学 高等职业技术学院，辽宁 沈阳 110026； 2.沈阳药科大学 药学院，辽宁 沈阳 110016)
摘要： 目的 通过对凝胶剂的体外累计释放百分率的比较，优化伊曲康唑凝胶剂的处方。方法 选用卡波姆-940作为凝胶剂的基质，用3种不同质量分数的伊曲康唑(ITZ)、甘油、PEG-400制备凝胶剂。采用Franz扩散池进行体外释放实验，正交设计优选处方。结果 优选的凝胶剂最佳处方为: ITZ质量分数为1%、PEG-400质量分数为10%、甘油质量分数为5%。结论 体外累积释放试验筛选伊曲康唑凝胶剂处方是可行的。
关键词： 药剂学; 伊曲康唑凝胶剂; 释放试验
中图分类号：R944 文献标识码：A
Optimizition of the formulation of itraconazole gels by release study in vitro
LI Fei1, YU Miao1, MA Ming-xin2, WANG Si-ling2, SU De-sen2
(1. Higher Vocational Technology Collage，Shenyang Pharmaceutical University, Shenyang 110026 China； 2，School of Pharmacy，Shenyang Pharmaceutical University, Shenyang 110016, China)
Abstract: Objective To optimize the formulation of itraconazole gels by release study in vitro. Methods Using carbopol-940 as the matrix of the gels, the optimal formulation of itraconazole gels was prepared by orthogonal experiment. Results The optimal formulation of itraconazole gels was ITZ of 1%, HP-β-CD of 30%, carbopol-940 of 2%, PEG-400 of 10% and glycerin of 5%. The accumulative release amounts of ITZ gels fitted Ritger-Peppas kinetic mechanism. Conclusion The method adopted for screening the formulation of the gels is feasible.
Key words: pharmaceutics; itraconazole gel; release test in vitro
李 飞1,于 淼1，马明欣2，王思玲2，苏德森2
(1.沈阳药科大学 高等职业技术学院，辽宁 沈阳 110026； 2.沈阳药科大学 药学院，辽宁 沈阳 110016)
摘要： 目的 通过对凝胶剂的体外累计释放百分率的比较，优化伊曲康唑凝胶剂的处方。方法 选用卡波姆-940作为凝胶剂的基质，用3种不同质量分数的伊曲康唑(ITZ)、甘油、PEG-400制备凝胶剂。采用Franz扩散池进行体外释放实验，正交设计优选处方。结果 优选的凝胶剂最佳处方为: ITZ质量分数为1%、PEG-400质量分数为10%、甘油质量分数为5%。结论 体外累积释放试验筛选伊曲康唑凝胶剂处方是可行的。
关键词： 药剂学; 伊曲康唑凝胶剂; 释放试验
中图分类号：R944 文献标识码：A
Optimizition of the formulation of itraconazole gels by release study in vitro
LI Fei1, YU Miao1, MA Ming-xin2, WANG Si-ling2, SU De-sen2
(1. Higher Vocational Technology Collage，Shenyang Pharmaceutical University, Shenyang 110026 China； 2，School of Pharmacy，Shenyang Pharmaceutical University, Shenyang 110016, China)
Abstract: Objective To optimize the formulation of itraconazole gels by release study in vitro. Methods Using carbopol-940 as the matrix of the gels, the optimal formulation of itraconazole gels was prepared by orthogonal experiment. Results The optimal formulation of itraconazole gels was ITZ of 1%, HP-β-CD of 30%, carbopol-940 of 2%, PEG-400 of 10% and glycerin of 5%. The accumulative release amounts of ITZ gels fitted Ritger-Peppas kinetic mechanism. Conclusion The method adopted for screening the formulation of the gels is feasible.
Key words: pharmaceutics; itraconazole gel; release test in vitro
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