关键词: 瘢痕疙瘩;基底膜;免疫组织化学;组织形态学

    摘 要:目的 观察瘢痕疙瘩(Ks)真皮表皮连接(DEJ)区结构变化. 方法 对瘢痕疙瘩浸润部、增生部和老化部及其正常皮肤(NS)标本，采用组织学、免疫组化laminin，vWF标记和DEJ区结构扫描电镜观察. 结果 DEJ区laminin和基底膜厚度、真皮乳头密度和乳头间孔穴密度，表皮内面基底细胞质膜皱襞密度、孔穴密度及其粘附细胞密度(EACD)，真皮乳头层微血管密度(MVD)等指标，各组均有显著的病理改变.统计学处理:浸润部>增生部>老化部或(和)正常皮肤(t，P<0.05～0.01).除真皮乳头和基底细胞质膜皱襞密度外，MVD或EACD与其他指标的均数间呈明显正相关(t，P<0.05～0.001，r=0.372～0.681). 结论 Ks不同部位DEJ区结构有显著不同的病理改变，可能与真皮乳头的微血管增生和阻塞及免疫细胞向表皮内大量浸润有关.

    Histomorphologic alterations of dermal┐epidermis junction in keloids

    JIANG Du-Yin，CHEN Bi，JIA Chi-Yu，DONG Mao-Long，XU Ming-Da

    Department of Burn Surgery，Plastic Surgery Cen-ter，Xijing Hospital，Fourth Military Medical Uni-versity，Xi'an710033，China

    Keywords:keloid;basement membrane;immunohis-tochemistry;histomorphology

    Abstract:AIM To observe the construction change of der-mal-epidermis junction(DEJ)in keloids(Ks).METHODS Histology，immunohistochemical labeling(laminin and vWF)and scanning electronic microscope were applied to investigate the invasiving zone，proliferative zone，aged zone of keloids and normal skin specimen.RESULTS There were marked pathological changes in laminin of DEJ ......