关键词: 磁刺激/经颅重复性;苍白球;黑质;酪氨酸羟化酶;免疫组织化学

    摘 要:目的 观察经颅重复性磁刺激(rTMS)对大鼠苍白球(GP)和黑质(SN)酪氨酸羟化酶(TH)阳性细胞及纤维变化的影响. 方法 采用置于大鼠头部的磁刺激器，每日予以1Hz，100mT的磁刺激10min，1次·d-1 ，共14d，然后免疫组织化学ABC法检测苍白球及黑质等部位TH免疫阳性产物的表达. 结果 较之假刺激组动物，rTMS后大鼠GP的TH免疫阳性纤维明显增多，尤以苍白球外侧部(GPe)和腹侧苍白球(VGP)明显;两组动物黑质致密部(SNC)和网状部(SNR)TH阳性标记的细胞数目未见明显差别，但rTMS组动物SNR和黑质外侧部(SNL)的TH阳性纤维数量有所增加. 结论 rTMS能够调整作为基底神经节主要输出结构的GP特别是GPe和SNR的多巴胺水平，推测在帕金森病等的治疗上有着一定的意义.

    Effects of repetitive transcranial magnetic stimula┐tion on tyrosine hydroxylase positive staining in rat globus pallibus and substantia nigra

    LIN Hong，SU Chang-Jun

    Department of Neurology，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China

    Keywords:rTMS;globus pallidus;substantia nigra;TH;immunohistochemistry

    Abstract:AIM To observe the effects of repetitive transcra-nial magnetic stimulation(rTMS)on tyrosine hydroxylase(TH)positive staining in rat globus pallibus and substantia nigra.METHODS Animals were treated with repetitive stimulation of1Hz ......