沙丁胺醇__(期刊论文)

沙丁胺醇包合物缓释片的释药机制研究

http://www.100md.com 《吉林医药医学学报》 2005年第3期

沙丁胺醇,,沙丁胺醇；乙基化β环糊精；包合物；释药机制,1仪器与试药,2方法与结果,3讨论,参考文献：

     摘要：目的研究沙丁胺醇包合物缓释片的释药机制。方法采用粉末直接压片法制备沙丁胺醇包合物缓释片，释放度测定采用《中华人民共和国药典》2000版二部释放度测定法中的第3法，用显色法测定释放介质中沙丁胺醇的浓度。结果经Peppas方程处理，扩散指数为0.667，相关系数为0.9990。结论沙丁胺醇缓释片以扩散和溶蚀协同作用释药。

    关键词：沙丁胺醇；乙基化β环糊精；包合物；释药机制

    Study on release mechanism of salbutamolethylated βcyclodextrins complexes sustained release tablets

    FENG Bo1, HE Zhonggui2, ZHANG Xiurong1, XU Yingai1, LI Jinghua1

    (1.Department of Pharmacy, Jilin Medical College, Jilin City, Jilin Province, 132013; 2.College of pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, 110016, China)

    Abstract:ObjectiveTo investigate the releasing mechanism of salbutamolethylated βcyclodextrins complexes inclusion sustained release tablets.MethodsSalbutamolethylated βcyclodextrins complexes sustained release tablets were made by powder tabletting method. The release rate was accquired according to Chinese Pharmacopoeia(2000).The concentration of salbutamol in the release medium was determined by colorimetric method. ResultsThe diffusion coefficient and relative coefficient of Peppas equation were 0.667 and 0.9990 respectively.ConclusionDiffusion and erosion occurred simultaneously in salbutamolethylated βcyclodextrins complexes sustained release tablets. ......

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