Effect comparison of three artificial liver support methods in treatment of hepatic failure

    HE Nianª²Hai, WANG Yingª²Jie, WANG Zeª²Wen, LIU Jun, LI Jiaª²Jia, LIU Guoª²Dong, WANG Yuª²Ming

    Research Institute of Infectious Disease, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

    ¡¾Abstract¡¿ AIM: Nonª²bioartificial liver was applied to clinic early, but the reported efficacy were very different. The aim of this article is to compare the efficacy and safety of hemoperfusion adsorption, plasma exchange and plasma exchange plus hemoperfusion adsorption in treatment of severe viral hepatitis. METHODS: Seventyª²five patients with severe viral hepatitis were treated with hemoperfusion adsorption therapy (24 cases), plasma exchange therapy (17 cases) and plasma exchange plus hemoperfusion adsorption therapy (34 cases). The data of liver function, renal function, blood routine test, prothrombin time (PT), prothrombin activity (PTa) preª² and postª²therapy were analyzed. RESULTS: Clinical symptoms of patients improved after treatment. The levels of aminotransferase, total bilirubin (TB), direct bilirubin (DB) decreased significantly after three therapies (P<0.05 or P<0.01), PT, the level of total serum proteins (TSP) decreased significantly and PTa increased significantly after plasma exchange therapy and plasma exchange plus hemoperfusion adsorption therapy (P<0.05 or P<0.01). The side effects were light and limited in all patients. CONCLUSION: Three therapies were effective in the treatment of severe viral hepatitis. Plasma exchange therapy and plasma exchange plus hemoperfusion adsorption therapy are better than hemoperfusion adsorption therapy. ......