微粒子捕捉酶免法_____甲钴胺；_微粒子捕捉酶免法；

甲钴胺片人体药代动力学和生物等效性

http://www.100md.com 《第四军医大学学报》 2004年第5期

微粒子捕捉酶免法,,甲钴胺；,微粒子捕捉酶免法；,药代动力学；,生物等效性,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Pharmacokinetics and relative bioequivalence of mecobalamin tablets in healthy volunteers

    LIN Lin, WEN AiDong, ZHAO Lei, WANG Meng, WU Yin, ZHANG SanQi

    Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an 710033, China

    【Abstract】 AIM： To ensure the quality of the medicine by comparing the pharmacokinetic parameters and the relative bioavailability of Chinamade and imported mecobalamin tablets. METHODS: An open, randomized, twoperiod crossover study with a twoweek washout interval was conducted in 24 healthy volunteers. Concentrations of mecobalamin in serum were assayed by MEIA method and the main pharmacokinetics parameters (AUC, Cmax and Tmax) were analyzed by two onesided t test. RESULTS: The AUC (0-72 h), Cmax and Tmax of tramadol were (5306±1801) ng/(h·L) and (5408±1828) ng/(h·L)，(286±101) ng/L and (270±98) ng/L,(3.0±0.9)h and(3.1±0.9)h, respectively. CONCLUSION: As the relative bioavailability of Chinamade and imported mecobalamin tablets are 99.2%, Chinamade and imported mecobalamin tablets are bioequivalent.

    【Keywords】 mecobalamin； microparticle enzyme immunoassay MEIA； pharmacokinetics； bioequivalence ......

百拇医药网 http://www.100md.com/html/DirDu/2006/02/19/87/11/55.htm

您现在查看是摘要页，全文长 11321 字符。