Tolerance of weekly scheduled administration of Doxetaxel in elder patients with breast cancer shortly after mammectomy

    HUANG Chen, YAO Qing, GAO Jianª²Yuan, LING Rui, ZHANG Juª²Liang

    1Department of Geriatrics, 2Department of Vascular and Endocrine Surgery, Xijing Hospital, Fourth Military Medical Univercity, Xi¡¯an 710033, China

    ¡¾Abstract¡¿ AIM: To discuss the tolerance of weekly scheduled administration of docetaxel in elder patients shortly following mammectomy. METHODS: Seventy elder patients with breast cancer were divided into 2 groups and Doxetaxel was administrated on the 3rd and 14th day respectively after operation. Healing of incision and response to chemotherapy were observed. RESULTS: There was no significant difference in incision healing between the two groups and the major sideª²effects at the early stage of chemotherapy were nausea and vomiting, which were relieved after treatment. The occurrence rate of group A and B was 41.9% and 44.4%, respectively. I-II grade leucopenia was found at the late stage of chemotherapy and the occurrence rate of group A and B was 16.3% and 14.8%, respectively. There was no significant difference between the two groups and no other severe side effects were observed in both groups. CONCLUSION: The weekly scheduled administration of docetaxel in elder patients shortly following mammectomy is safe and well tolerated. ......