颅脑损伤__(期刊论文)

亚低温对颅脑损伤患者血清细胞因子的影响

http://www.100md.com 《第四军医大学学报》 2003年第7期

颅脑损伤,,颅脑损伤；亚低温；白介素1β；白介素6；,肿瘤坏死因子α,0引言,1对象和方法,2结果,3讨论,【参考文献】

     (兰州医学院第二医院神经外科，甘肃兰州 730030)

    Effect of mild hypothermia on serum cytokines after traumatic brain injury

    ZHANG YongHong, ZHANG JianSheng, DING YongZhong, WANG WeiPing

    Department of Neurosurgery, Second Hospital, Lanzhou Medical College, Lanzhou 730030, China

    【Abstract】 AIM: To study the effect and clinical significance of mild hypothermia on serum interleukin1β, interleukin6 and tumor necrosis factorαlevels in patients after traumatic brain injury. METHODS: 48 patients with traumatic brain injury were divided into two groups randomly. 25 cases of the hypothermia group underwent hypothermia of 33～35℃ for 35 days after injury, and 23 cases of the normothermic group were maintained at normothermic levels (36～37℃). By using radioimmunoassay, serum IL1β, IL6 and TNFα levels at 1, 3, 5, 10 d after injury were measured. Other 15 voluntary heathy people were selected to determine normal ranges. RESULTS: The serum IL1β, IL6 and TNFα levels ﹙μg·L-1﹚ in the injury patients were 60.7±9.1, 100.5±24.4, 17.7±4.2 respectively, significantly higher than that of heathy people 33.6±13.5, 58.3±5.3, 9.1±0.6. In the hypothermia group, the serum IL1β, IL6 and TNFαl evels were significantly lower than the normothermic group. CONCLUSION: Serum IL1β, IL6 and TNFα levels are increased after traumatic brain injury; and mild hypothermia therapy can decrease them. ......

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