Possible Lª²Enk mechanism of hemodynamics changes in rabbits with multiple organ dysfunction syndrome following burns

    LIU Yaª²Ling, LIN Shuª²Xin, LI Zhiª²Chao, CHEN Bi, ZHANG Shiª²Fan

    1Department of Burn Surgery, Center of Plastic Surgery, Xijing Hospital, 2Department of Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi¬ðan 710033, China, 3Department of Cardiothoracic Surgery, General Hospital, Lanzhou Military Command, Lanzhou 730000, China

    ¡¾Abstract¡¿ AIM: To observe the changes of leucineª²enkephalin (Lª²Enk) content in the arteries of rabbits in early stage after burn and to study the effects of Lª²Enk in the arteries on the hemodynamics changes at early stage following burns. METHODS: The rabbits were divided into 3 groups, the sham burn group (SB), burn group (B), and burn and Naloxone therapy group (BN). The mean arterial pressure (MAP), central venous pressure (CVP) and cardiac output (CO) were monitored and the systemic vascular resistance (SVR) and cardiac index (CI) were calculated. The levels of serum creatine phosphokinase (CK), glutamic pyruvic transaminase (GPT), blood urea nitrogen (BUN), creatinine (Cr), blood platelet count (PLT) and HB were detected. RESULTS: ¢Ù In comparison with those in SB, the Lª²Enk contents of mesenteric artery, renal artery and pulmonary artery decreased significantly in group B. ¢Ú In comparison with those in group B, the CK, GPT and BUN did not change markedly in BN group. CONCLUSION: The decreasing of Lª²Enk contents in arteries may be responsible for the contraction of microvessels, the increase of SVR, and the damage of organ functions. ......