蛋白酶抑制剂_____乌司他丁；胆汁郁积；胰蛋白酶抑制剂

乌司他丁在梗阻性黄疸中抗感染的实验研究

http://www.100md.com 《第四军医大学学报》 2003年第8期

蛋白酶抑制剂,,乌司他丁；胆汁郁积；胰蛋白酶抑制剂,0引言,1材料和方法,2结果,3讨论,【参考文献】

     (第四军医大学西京医院:肝胆外科，检验科，陕西西安710033)

    Research of the effect of ulinastatin on infection of rats with obstructive jaundice

    FENG QuanXin，DOU KeFeng，LI HaiMin，ZHEN ShanLan，SUN YiQun，PENG DaoRong

    Department of Hepatobiliary Surgery, Clinical Laboratory，Xijing Hospital，Fourth Military Medical University，Xian 710033,China

    【Abstract】AIM：To study the effects of ulinastatin (UTI) on infection of rats with obstructive jaundice.METHODS: Eighty SD rats were assigned randomly into four groups: Control group (A), UTI group (B), prevent group (C) and pseudoperation group (D), and were sacrificed seven days late. A, B and C groups were operated on, the common bile-duct was ligated. UTI was given intraperitoneally at the dosage of 40 000 IU/kg/d in UTI group at the first day of postoperation and in prevent group at the previous day of preoperation. In the control and pseudoperation groups, 0.9% NS was given intraperitoneally at the first day of postoperation. When the rats were sacrificed, their blood was taken for blood routine and germ culture A small part of the live was taken for light microscopic examination. RESULTS: The WBC levels of A, B, C and D groups were (194±24)×109 ·L-1, (149±23)×109 ·L-1, (110±27)×109 ·L-1 and (92±18)×109 ·L-1, respectively, which were significantly different (P<001). By light microscopic examination, the degeneration of hepatocytes and neutrophil infiltration in the liver in A, B and C groups was observed. The changes in A group was more obvious than those in the other groups and focal necrosis of hepatocytes and lobules damage were also observed. CONCLUSION: UTI has a significant preventive effects on the infection of rats with obstructive jaundice. ......

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