宫颈肿瘤_____他莫昔芬;宫颈肿瘤;细胞分裂

他莫西芬促进HeLa 宫颈癌细胞系增殖

http://www.100md.com 《第四军医大学学报》 2003年第6期

宫颈肿瘤,,他莫昔芬;宫颈肿瘤;细胞分裂,他莫西芬促进HeLa宫颈癌细胞系增殖,0引言,1材料和方法,2结果,3讨论,【参考文献】

     (第四军医大学基础部生理学教研室，陕西西安 710033)

    Stimulation of tamoxifen on the proliferation of cultured HeLa cervical carcinoma cell line

    ZOU ZiYing, ZHU YunLong, WANG GaoFeng, ZHONG YanQing, ZHOU Hua, Liu YaLi

    Department of Physiology, Faculty of Preclinical Medicine,Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM： To investigate whether tamoxifen is involved in the proliferation of cultured HeLa cell line, which is derived from cervical carcinoma cell line of human beings. METHODS： The level of cell proliferation was assessed by drawing the proliferation curves of HeLa cells, detecting OD value of MTT assay and using flow cytometry and laser scanning confocal microscope. RESULTS： Tamoxifen (1×10-7 mol·L-1) shifted the curve upward. Tamoxifen (1×10-8~1×10-6 mol·L-1) significantly stimulated the cell proliferation and facilitated (1×10-6 mol·L-1) G1/S transfer of the cell cycle as well as greatly increased the releasing of Ca2+ in the cells. CONCLUSION： Tamoxifen may modulate the proliferation and the differentiation of cultured HeLa cervical carcinoma cells by affecting the cell cycle and Ca2+ in the cells. ......

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