黄芩及大黄的体内代谢及分析方法研究进展.PDF
http://www.100md.com
2006年2月23日
| 第1页 |
参见附件(86KB，3页)。
动物模型 ,药物治疗 AD 的效果难以评价。中医药在治疗
AD的研究方面起步较晚 ,研究相对较少 ,多是停留在低级重
复和动物实验阶段 ,尤其对中药单体或有效成分的治疗机理
缺乏深入的研究 ,加之 AD发病机制的复杂性和进行临床研
究的难度 ,因此 ,中药防治AD研究的路还很长。
参考文献:
[ 1 ] Zhao Q ,Tang X C. Effects of huperzine A on acetylcholinesterase
isoforms in vit ro : comparison with tacrine , donepezil , rivastig2
mine and physostigmine[J ] . Eur J Pharmacol . 2002 ,455 (223) :
10127.
[ 2 ] 陈美娟,高之旭.石杉碱甲胶囊和片剂治疗阿尔采夫病的多种
心双盲研究[J ] .中国新药与临床,2000 ,19 (1) :10212.
[ 3 ] 熊志琦. 石杉碱类似物异香蓝石杉碱甲对胆碱脂酶的抑制作
用和东莨菪碱导致的记忆障碍作用[J ] .中国药理学报,1995 ,16 (1) :1225.
[ 4 ] 医学信息杂志,2000 ,13 (1) :324.
[ 5 ] Graih N H , Pei X F ,Soncrant T T ,et al . Phenserine and ring
Chetero2analogues : drug candidates for the t reatment of
Alzheimer’ s Disease[J ] . Med Res Rev ,1995 ,15 :327.
[ 6 ] Howes M J ,Perry N S ,Houghton P J . Plants with t raditional us2
es and activities , relevant to the management of Alzheimer’ s dis2
ease and other cognitive disorders [ J ] . Phytother Res , 2003 , 17
(1) :1218.
[ 7 ] Olney J W, Woziak D F , Farber N B. Excitotoxic neurode2
generation in Alzheimer’ s disease , New hypothesis and new
therapeutic st rategies[J ] . A rch Neurol , 1997 , 54 (10) : 1234.
[ 8 ] 沈丽霞.蛇床子素对学习记忆的影响及其机制分析. 药学学
报,1999 ,34 (6) :405.
[ 9 ] 唐民科,张均田.丹酚酸B体外抑制淀粉样β蛋白的纤维形成
及其细胞毒作用[J ] .中国药理学报,2001 ,22 (4) :3802384.
[ 10 ] 段光琳,董梅,吴建梁.李琳大黄素对βAP毒性作用的神经元
的保护作用[J ] .中华医学研究杂志,2002 ,2 (1) :123.
[ 11 ] 陈勤,夏宗勤,胡雅儿.知母皂苷元对拟痴呆大鼠β 2淀粉样肽
沉积及胆碱能系统功能的影响[J ] .中国药理学通报,2002 ,18
(4) :3902393.
[12 ] 庾照学,汗华侨,袁群芳,等.抗氧化剂 TA9901 抑制加速老化
鼠脑淀粉样颗粒的沉积[J ] .解剖学报,2002 ,33 (1) :28232.
[ 13 ] Feng Z , Zhang J T. Effects of salivianolic acid B on beta2amyloid
peptide neurotoxicity of primary cultured fetal rat cortical neu2
rons[J ] . Yao Xue Xue Bao , 2000 , 35 (12) :88125.
[14 ] Choi YT , J ung CH , Lee SR , et al . The green tea polyphenol
(2)2epigallocatechin gallate attenuates beta2amyloid2induced neu2
rotoxicity in cultured hippocampal neurons[J ] . L if e Sci , 2001 ,70 (5) :603214.
[15 ] Bastianetto S , Zheng W H , Quirion R. The Ginkgo biloba ex2
t ract ( EGb 761) protects and rescues hippocampal cells against
nit ric oxide2induced toxicity : involvement of its flavonoid con2
stituents and protein kinase C[J ] . J Neurochem. 2000 , 74 (6) :
2268277.
[ 16 ] Lam B Y, Lo A C , Sun X , et al . Neuroprotective effects of tan2
shinones in t ransient focal cerebral ischemia in mice [J ] . Sucher
NJ . Phytomedici ne , 2003 , 10 (4) :286291.
[ 17 ] Yu SR , Gao NN , Li LL , et al . The protective effect of 32butyl
phthalide 6n rat brain cells [J ] . Yao Xue Xue Bao , 1988 , 23
(9) :656261.
[ 18 ] Gong YS , Zhang J T. Effect of 172beta2est radiol and ginsenoside
Rgl on reactive microglia induced by beta2amyloid peptides[J ] . J
Asian Nat Prod Res , 1999 , 1 (3) :153261.
[ 19 ] 赵晓民,谢湘林,等. 人参茎叶皂甙和胆碱合用对喹啉酸损毁
基底核大鼠学习记忆的影响[J ] . 中国药理学和毒理学杂志,2000 ,14 (6) :4172420.
[ 20 ] McKenna D J , Jones K, Hughes K. Efficacy , safety and use of
ginkgo biloba in clinical and preclinical applications[J ] . A Itern
Ther Heal th Med , 2001 , 7 (5) :70286 , 88290.
[21 ] 孙萍,盛丽,张予阳,等. 银杏内酯对小鼠和大鼠脑缺血的保
护作用[J ] . 中国药理学通报,2001 ,17 (6) :6672669.
[ 22 ] Duan W Z , Zhang J T. Stimulation of cent ral cholinergic neurons
by (2) clausenamide in vit ro [ J ] . Zhongguo Yao L i Xue Bao ,1998 , 19 (4) :33226. ......
AD的研究方面起步较晚 ,研究相对较少 ,多是停留在低级重
复和动物实验阶段 ,尤其对中药单体或有效成分的治疗机理
缺乏深入的研究 ,加之 AD发病机制的复杂性和进行临床研
究的难度 ,因此 ,中药防治AD研究的路还很长。
参考文献:
[ 1 ] Zhao Q ,Tang X C. Effects of huperzine A on acetylcholinesterase
isoforms in vit ro : comparison with tacrine , donepezil , rivastig2
mine and physostigmine[J ] . Eur J Pharmacol . 2002 ,455 (223) :
10127.
[ 2 ] 陈美娟,高之旭.石杉碱甲胶囊和片剂治疗阿尔采夫病的多种
心双盲研究[J ] .中国新药与临床,2000 ,19 (1) :10212.
[ 3 ] 熊志琦. 石杉碱类似物异香蓝石杉碱甲对胆碱脂酶的抑制作
用和东莨菪碱导致的记忆障碍作用[J ] .中国药理学报,1995 ,16 (1) :1225.
[ 4 ] 医学信息杂志,2000 ,13 (1) :324.
[ 5 ] Graih N H , Pei X F ,Soncrant T T ,et al . Phenserine and ring
Chetero2analogues : drug candidates for the t reatment of
Alzheimer’ s Disease[J ] . Med Res Rev ,1995 ,15 :327.
[ 6 ] Howes M J ,Perry N S ,Houghton P J . Plants with t raditional us2
es and activities , relevant to the management of Alzheimer’ s dis2
ease and other cognitive disorders [ J ] . Phytother Res , 2003 , 17
(1) :1218.
[ 7 ] Olney J W, Woziak D F , Farber N B. Excitotoxic neurode2
generation in Alzheimer’ s disease , New hypothesis and new
therapeutic st rategies[J ] . A rch Neurol , 1997 , 54 (10) : 1234.
[ 8 ] 沈丽霞.蛇床子素对学习记忆的影响及其机制分析. 药学学
报,1999 ,34 (6) :405.
[ 9 ] 唐民科,张均田.丹酚酸B体外抑制淀粉样β蛋白的纤维形成
及其细胞毒作用[J ] .中国药理学报,2001 ,22 (4) :3802384.
[ 10 ] 段光琳,董梅,吴建梁.李琳大黄素对βAP毒性作用的神经元
的保护作用[J ] .中华医学研究杂志,2002 ,2 (1) :123.
[ 11 ] 陈勤,夏宗勤,胡雅儿.知母皂苷元对拟痴呆大鼠β 2淀粉样肽
沉积及胆碱能系统功能的影响[J ] .中国药理学通报,2002 ,18
(4) :3902393.
[12 ] 庾照学,汗华侨,袁群芳,等.抗氧化剂 TA9901 抑制加速老化
鼠脑淀粉样颗粒的沉积[J ] .解剖学报,2002 ,33 (1) :28232.
[ 13 ] Feng Z , Zhang J T. Effects of salivianolic acid B on beta2amyloid
peptide neurotoxicity of primary cultured fetal rat cortical neu2
rons[J ] . Yao Xue Xue Bao , 2000 , 35 (12) :88125.
[14 ] Choi YT , J ung CH , Lee SR , et al . The green tea polyphenol
(2)2epigallocatechin gallate attenuates beta2amyloid2induced neu2
rotoxicity in cultured hippocampal neurons[J ] . L if e Sci , 2001 ,70 (5) :603214.
[15 ] Bastianetto S , Zheng W H , Quirion R. The Ginkgo biloba ex2
t ract ( EGb 761) protects and rescues hippocampal cells against
nit ric oxide2induced toxicity : involvement of its flavonoid con2
stituents and protein kinase C[J ] . J Neurochem. 2000 , 74 (6) :
2268277.
[ 16 ] Lam B Y, Lo A C , Sun X , et al . Neuroprotective effects of tan2
shinones in t ransient focal cerebral ischemia in mice [J ] . Sucher
NJ . Phytomedici ne , 2003 , 10 (4) :286291.
[ 17 ] Yu SR , Gao NN , Li LL , et al . The protective effect of 32butyl
phthalide 6n rat brain cells [J ] . Yao Xue Xue Bao , 1988 , 23
(9) :656261.
[ 18 ] Gong YS , Zhang J T. Effect of 172beta2est radiol and ginsenoside
Rgl on reactive microglia induced by beta2amyloid peptides[J ] . J
Asian Nat Prod Res , 1999 , 1 (3) :153261.
[ 19 ] 赵晓民,谢湘林,等. 人参茎叶皂甙和胆碱合用对喹啉酸损毁
基底核大鼠学习记忆的影响[J ] . 中国药理学和毒理学杂志,2000 ,14 (6) :4172420.
[ 20 ] McKenna D J , Jones K, Hughes K. Efficacy , safety and use of
ginkgo biloba in clinical and preclinical applications[J ] . A Itern
Ther Heal th Med , 2001 , 7 (5) :70286 , 88290.
[21 ] 孙萍,盛丽,张予阳,等. 银杏内酯对小鼠和大鼠脑缺血的保
护作用[J ] . 中国药理学通报,2001 ,17 (6) :6672669.
[ 22 ] Duan W Z , Zhang J T. Stimulation of cent ral cholinergic neurons
by (2) clausenamide in vit ro [ J ] . Zhongguo Yao L i Xue Bao ,1998 , 19 (4) :33226. ......
您现在查看是摘要介绍页，详见PDF附件(86KB，3页)。