冷缺血时间及组织相容性对胰岛细胞活性的影响
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高宏君, 徐达传, 赵 明, 李 民, 范礼佩,
胰岛细胞;冷缺血;相容性;移植,高宏君,赵明,李民,范礼佩,李留洋,钱俊,蔡德鸿,徐达传,高宏君,通讯作者:,Influenceofcoldische
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高宏君, 赵明, 李民, 范礼佩, 李留洋, 钱俊, 蔡德鸿, 南方医科大学附属珠江医院器官移植科 广东省广州市 510280
徐达传, 南方医科大学解剖学教研室 广东省广州市 510515
高宏君, 男, 1972-05-18, 吉林省长春人, 满族, 1995年吉林大学(原白求恩医科大学)博士, 主治医师, 主要从事器官移植方面的研究.
通讯作者: 高宏君, 510280, 广东省广州市海珠区工业大道, 南方医科大学附属珠江医院器官移植科. gao4056@163.com
电话: 0771-2188219 传真：0771-2188219
收稿日期: 2005-08-29 接受日期: 2005-09-06
Influence of cold ischemia preservation time and histocompatibility on activity of islet cells
Hong-Jun Gao, Da-Chuan Xu, Ming Zhao, Min Li, Li-Pei Fan, Liu-Yang Li, Jun Qian, De-Hong Cai
Hong-Jun Gao, Ming Zhao, Min Li, Li-Pei Fan, Liu-Yang Li, Jun Qian, De-Hong Cai, Department of Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China
Da-Chuang XU, Department Of Anatomy, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Supported by the Natural Science Foundation of Guangdong Province, No. 980240
Correspondence to: Dr. Hong-Jun Gao, Department of Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China. gao4056@163.com
Received: 2005-08-29 Accepted: 2005-09-06
Abstract
AIM: To investigate the impacts of cold ischemia preservation time and histocompatibility on the activity of islet cells during the islet transplan-tation.
METHODS: Pancreas was obtained from brain-dead donors, whose blood and HLA types were known. After in situ perfusion with hypertonic citrate adenine solution (HC-A) via aorta, the liver, kidney, and pancreas were resected in combination or separately. The changes of islet cell activity under different time of cold ischemia preservation were observed. The compatibility of islet cells with recipients was detected and the relationship between the histocompatibility and islet cell survival were analyzed.
RESULTS: Resection in combination or alone was successfully performed, and the rate of islet cell activity was all above 80% after cold ischemia for 5 h ......
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