TLR4基因多态性与慢性胃炎幽门螺杆菌感染无相关性
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华开罗, 夏 冰, 李 春, 郭秋莎
Toll样受体4;幽门螺杆菌;基因多态性,华开罗,夏冰,通讯作者:,李春,NoassociationbetweenToll-likerecep
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华开罗, 武汉大学医学院附属中山医院消化内科 湖北省武汉市 430033
夏冰, 武汉大学中南医院综学中南医院综合医疗科, 湖北省武汉市 430071
通讯作者: 夏冰, 430071, 湖北合医疗科 湖北省武汉市 430071
李春, 郭秋莎, 武汉大省武汉市东湖路169号, 武汉大学中南医院消化内科. bingxia2004@yahoo.com.cn
电话: 027-67812985-2985 传真: 027-87330795
收稿日期: 2005-12-22 接受日期: 2006-01-26
No association between Toll-like receptor-4 gene polymorphism and Helicobacter pylori infection in chronic gastritis
Kai-Luo Hua, Bing Xia, Chun Li, Qiu-Sha Guo
Kai-Luo Hua, Department of Gastroenterology, the Affiliated Zhongshan Hospital of Wuhan University School of Medicine, Wuhan 430033, Hubei Province, China
Bing Xia, Department of Internal Medicine and Geriatrics, Research Center of Digestive Diseases, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan 430071, Hubei Province, China
Chun Li, Qiu-Sha Guo, Department of Internal Medicine and Geriatrics, Research Center of Digestive Diseases, Zho-ngnan Hospital, Key Lab of Allergy and Immune-relaed Diseases, Wuhan 430071, Hubei Province, China
Correspondence to: Bing Xia, Department of Internal Medicine and Geriatrics, Research Center of Digestive Diseases, Zhongnan Hospital, Wuhan University School of Medicine, 169 Donghu Road, Wuhan 430071, Hubei Province, China. bingxia2004@yahoo.com.cn
Received: 2005-12-22 Accepted: 2006-01-26
Abstract
Aims: To study the distribution of Toll-like receptor-4 (TLR4) gene Asp299Gly poly-morp-hism and to define association between TLR4 genotype and Helicobacter Pylori asso-ciated chronic gastritis in Han Chinese of Hubei province.
Methods: One hundred and fifteen patients with chronic superficial gastritis and 264 healthy controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method for TLR4 gene Asp299Gly polymorphism. Meanwhile, H pylori infection was also detected in all the individuals.
Results: The rate of H pylori infection was 89 ......
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